Table 1 Characteristics of 17Poly-miRTS in Ara-C/anthracyclines pathway genes
Gene | SNP ID | Chromosome location | Positiona | Variants | MAF in CHB | Putative miRNA and effectb |
|---|---|---|---|---|---|---|
SLC29A1 | rs3734703 | 6 | 44233997 | C>A | 0.20 | hsa-miR-1207-5p (break) hsa-miR-571 (decrease) |
NT5C2 | rs10786736 | 10 | 103089359 | G>C | 0.22 | hsa-miR-581 (break) hsa-miR-1238 (enhance) hsa-miR-1236 (decrease) |
rs8139 | 10 | 103088366 | T>C | 0.50 | hsa-miR-373 (break) hsa-miR-578 (break) hsa-miR-125a-3p (create) | |
rs12573199 | 10 | 103089087 | A>T | 0.08 | hsa-miR-325 (create) hsa-miR-548a-5p (break) | |
DCTD | rs3811810 | 4 | 182890990 | G>A | 0.08 | hsa-miR-574-5p (create) hsa-miR-599 (create) |
rs7278 | 4 | 182890334 | C>T | 0.17 | hsa-miR-935 (decrease) | |
rs851 | 4 | 182890517 | G>A | 0.30 | hsa-miR-1288 (create) hsa-miR-423-5p (enhance) hsa-miR-556-5p (create) | |
rs9542 | 4 | 182891198 | G>A | 0.47 | hsa-miR-1305 (break) | |
RRM1 | rs1042919 | 11 | 4138534 | T>A | 0.32 | hsa-miR-944 (enhance) |
SLC28A1 | rs8025045 | 15 | 84945341 | G>T | 0.06 | hsa-miR-500 (create) hsa-miR-574-3p (decrease) hsa-miR-767-3p (decrease) |
CBR1 | rs9024 | 21 | 36073015 | G>A | 0.20 | hsa-miR-944 (break) hsa-miR-325 (enhance) |
ABCB1 | rs3842 | 7 | 87504050 | A>G | 0.28 | hsa-miR-548g (break) |
ABCC1 | rs212090 | 16 | 16142147 | T>A | 0.14 | hsa-miR-1292 (break) hsa-miR-548j (break) hsa-miR-450b-3p (create) hsa-miR-769-3p (create) hsa-miR-199a-3p (decrease) hsa-miR-199b-3p (decrease) |
rs212091 | 16 | 16142793 | A>G | 0.26 | hsa-miR-1303 (create) | |
rs3743527 | 16 | 16141824 | C>T | 0.45 | hsa-miR-625 (break) hsa-miR-141 (break) hsa-miR-760 (break) hsa-miR-1291 (enhance) | |
rs4148380 | 16 | 16142574 | G>A | 0.05 | hsa-miR-187 (break) hsa-miR-599 (create) | |
NQO1 | rs10517 | 16 | 69709857 | C>T | 0.37 | hsa-miR-1243 (create) hsa-miR-587 (create) hsa-miR-324-5p (enhance) |