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TableĀ 1 Characteristics of 17Poly-miRTS in Ara-C/anthracyclines pathway genes

From: Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

Gene SNP ID Chromosome location Positiona Variants MAF in CHB Putative miRNA and effectb
SLC29A1 rs3734703 6 44233997 C>A 0.20 hsa-miR-1207-5p (break)
hsa-miR-571 (decrease)
NT5C2 rs10786736 10 103089359 G>C 0.22 hsa-miR-581 (break)
hsa-miR-1238 (enhance)
hsa-miR-1236 (decrease)
rs8139 10 103088366 T>C 0.50 hsa-miR-373 (break)
hsa-miR-578 (break)
hsa-miR-125a-3p (create)
rs12573199 10 103089087 A>T 0.08 hsa-miR-325 (create)
hsa-miR-548a-5p (break)
DCTD rs3811810 4 182890990 G>A 0.08 hsa-miR-574-5p (create)
hsa-miR-599 (create)
rs7278 4 182890334 C>T 0.17 hsa-miR-935 (decrease)
rs851 4 182890517 G>A 0.30 hsa-miR-1288 (create)
hsa-miR-423-5p (enhance)
hsa-miR-556-5p (create)
rs9542 4 182891198 G>A 0.47 hsa-miR-1305 (break)
RRM1 rs1042919 11 4138534 T>A 0.32 hsa-miR-944 (enhance)
SLC28A1 rs8025045 15 84945341 G>T 0.06 hsa-miR-500 (create)
hsa-miR-574-3p (decrease)
hsa-miR-767-3p (decrease)
CBR1 rs9024 21 36073015 G>A 0.20 hsa-miR-944 (break)
hsa-miR-325 (enhance)
ABCB1 rs3842 7 87504050 A>G 0.28 hsa-miR-548g (break)
ABCC1 rs212090 16 16142147 T>A 0.14 hsa-miR-1292 (break)
hsa-miR-548j (break)
hsa-miR-450b-3p (create)
hsa-miR-769-3p (create)
hsa-miR-199a-3p (decrease)
hsa-miR-199b-3p (decrease)
rs212091 16 16142793 A>G 0.26 hsa-miR-1303 (create)
rs3743527 16 16141824 C>T 0.45 hsa-miR-625 (break)
hsa-miR-141 (break)
hsa-miR-760 (break)
hsa-miR-1291 (enhance)
rs4148380 16 16142574 G>A 0.05 hsa-miR-187 (break)
hsa-miR-599 (create)
NQO1 rs10517 16 69709857 C>T 0.37 hsa-miR-1243 (create)
hsa-miR-587 (create)
hsa-miR-324-5p (enhance)
  1. aObtained from NCBI: Assembly: GRCh38.p7
  2. bObtained from https://snpinfo.niehs.nih.gov/