Characteristics | |
---|---|
Routine | Technic to be performed by pathologist using bright field and precise cell evaluation |
Feasible | Established pathology technics, using 2 regular whole slide FFPE section |
Inexpensive | Automatized immunohistochemistry |
Rapid | 2 simple staining less costly than complicated molecular techniques |
Robust | Autostainers, scanner, and digital pathology reduce the time to perform an Immunoscore |
Reproducible | Two strong membrane staining, with no background, allowing the numeration of individual cells |
Quantitative | Inter-observers variability is removed by the use of digital pathology, taking into account cell location and counts |
Standardized | Standardized operating procedure should be performed to insure reproducibility and worldwide comparisons |
Pathology-based | Necessity of pathologist expertise to validate cell type, cell location, and cell counts performed by digital pathology |
Powerful | The Immunoscore has a prognostic value highly significant even in Cox multivariate including TNM classification |