Fig. 2
Tumor interstitial fluid pressure (IFP) and fraction of hypoxic tissue (HFPim) in two groups of human melanoma xenografts differing in metastatic pattern. N-15, R-18, and T-22 tumors showed higher IFP than C-10, D-12, and E-13 tumors (a), but did not differ from C-10, D-12, and E-13 tumors in HFPim (b). Columns and bars: mean values ± standard error (n = 50 in a and n = 20 in b, where n represents the number of examined tumors). The experiments were carried out by using adult (8–12 weeks of age) female BALB/c nu/nu mice as host animals