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Table 3 Serial measurements of the left and right ventricular systolic and diastolic parameters

From: Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension

  Baseline 3 months FUP 5 months FUP
HYPI (n = 7) Control (n = 5) HYPI (n = 7) Control (n = 5) HYPI (n = 7) Control (n = 5)
Invasive pressure–volume loop measurements
 End-diastolic volume (mL) 87 ± 3 81 ± 6 127 ± 13 109 ± 25 133 ± 12 125 ± 10
 End-systolic volume (mL) 38 ± 2 32 ± 7 54 ± 6 44 ± 12 53 ± 11 44 ± 4
 Stroke volume (mL) 49 ± 5 49 ± 4 73 ± 8 65 ± 21 78 ± 9 81 ± 14
 LV ejection fraction (%) 56 ± 4 60 ± 7 58 ± 3 59 ± 9 59 ± 4 65 ± 5
 Stroke work (mmHg*mL) 4497 ± 145 4492 ± 1182 8692 ± 1017* 4813 ± 858 9407 ± 1027* 5335 ± 741
 Cardiac output (L/min) 4.0 ± 0.2 4.4 ± 0.4 5.4 ± 0.8 5.2 ± 0.8 5.8 ± 0.8 5.8 ± 0.8
 LV maximal pressure (mmHg) 105 ± 15 118 ± 14 150 ± 11* 124 ± 15 169 ± 18* 120 ± 5
 LV minimum pressure (mmHg) 5 ± 2 2 ± 5 13 ± 3* 6 ± 2 14 ± 3* 6 ± 2
 LV maximum dP/dt (mmHg/s) 1106 ± 164 1203 ± 155 1693 ± 679 1436 ± 136 1883 ± 384 1594 ± 276
 LV minimum dP/dt (mmHg/s) −1492 ± 246 −1485 ± 433 −1741 ± 126 −1620 ± 228 −1911 ± 480 −1616 ± 231
 Mean arterial pressure (mmHg) 57 ± 9 60 ± 22 82 ± 7* 61 ± 4 91 ± 11* 68 ± 3
 LV maximal dV/dt (mL/s) 428 ± 135 428 ± 58 693 ± 94 592 ± 186 527 ± 89* 425 ± 57
 Arterial elastance (mmHg/mL) 2.4 ± 0.4 2.5 ± 0.2 3.0 ± 0.9 2.5 ± 0.3 3.2 ± 0.7* 2.4 ± 0.2
 Tau (ms) 23.8 ± 6.7 25.7 ± 5.8 32.5 ± 1.9 26.8 ± 3.3 39.1 ± 8.2* 24.9 ± 4.7
MRI at 5 months
 LV end-diastolic volume (mL)      128 ± 16 109 ± 12
 LV end-systolic volume (mL)      52 ± 10 38 ± 8
 LV stroke volume (mL)      76 ± 12 72 ± 10
 LV ejection fraction (%)      59 ± 6 66 ± 6
 LV mass (g)      151 ± 27 95 ± 17
 RV end-diastolic volume (mL)      97 ± 13* 78 ± 5
 RV end-systolic volume (mL)      53 ± 15 37 ± 4
 RV ejection fraction (%)      47 ± 10 52 ± 6
 RV mass (g)      82 ± 9 57 ± 6
 LV peak filling rate (mL/s)      349 ± 114* 514 ± 81
  1. Data were collected using invasive pressure measurements with pressure–volume loop catheter in hypertrophic pigs (HYPI) and in controls
  2. Italics Parameters characterizing LV hypertrophy
  3. LV left ventricular, RA right atrial, RV right ventricular
  4. * p < 0.01 for pressure–volume loop and MRI parameter (ANOVA after Bonferroni correction) between the groups at the same time point