Baseline | 3 months FUP | 5 months FUP | ||||
---|---|---|---|---|---|---|
HYPI (n = 7) | Control (n = 5) | HYPI (n = 7) | Control (n = 5) | HYPI (n = 7) | Control (n = 5) | |
Invasive pressure–volume loop measurements | ||||||
End-diastolic volume (mL) | 87 ± 3 | 81 ± 6 | 127 ± 13 | 109 ± 25 | 133 ± 12 | 125 ± 10 |
End-systolic volume (mL) | 38 ± 2 | 32 ± 7 | 54 ± 6 | 44 ± 12 | 53 ± 11 | 44 ± 4 |
Stroke volume (mL) | 49 ± 5 | 49 ± 4 | 73 ± 8 | 65 ± 21 | 78 ± 9 | 81 ± 14 |
LV ejection fraction (%) | 56 ± 4 | 60 ± 7 | 58 ± 3 | 59 ± 9 | 59 ± 4 | 65 ± 5 |
Stroke work (mmHg*mL) | 4497 ± 145 | 4492 ± 1182 | 8692 ± 1017* | 4813 ± 858 | 9407 ± 1027* | 5335 ± 741 |
Cardiac output (L/min) | 4.0 ± 0.2 | 4.4 ± 0.4 | 5.4 ± 0.8 | 5.2 ± 0.8 | 5.8 ± 0.8 | 5.8 ± 0.8 |
LV maximal pressure (mmHg) | 105 ± 15 | 118 ± 14 | 150 ± 11* | 124 ± 15 | 169 ± 18* | 120 ± 5 |
LV minimum pressure (mmHg) | 5 ± 2 | 2 ± 5 | 13 ± 3* | 6 ± 2 | 14 ± 3* | 6 ± 2 |
LV maximum dP/dt (mmHg/s) | 1106 ± 164 | 1203 ± 155 | 1693 ± 679 | 1436 ± 136 | 1883 ± 384 | 1594 ± 276 |
LV minimum dP/dt (mmHg/s) | −1492 ± 246 | −1485 ± 433 | −1741 ± 126 | −1620 ± 228 | −1911 ± 480 | −1616 ± 231 |
Mean arterial pressure (mmHg) | 57 ± 9 | 60 ± 22 | 82 ± 7* | 61 ± 4 | 91 ± 11* | 68 ± 3 |
LV maximal dV/dt (mL/s) | 428 ± 135 | 428 ± 58 | 693 ± 94 | 592 ± 186 | 527 ± 89* | 425 ± 57 |
Arterial elastance (mmHg/mL) | 2.4 ± 0.4 | 2.5 ± 0.2 | 3.0 ± 0.9 | 2.5 ± 0.3 | 3.2 ± 0.7* | 2.4 ± 0.2 |
Tau (ms) | 23.8 ± 6.7 | 25.7 ± 5.8 | 32.5 ± 1.9 | 26.8 ± 3.3 | 39.1 ± 8.2* | 24.9 ± 4.7 |
MRI at 5 months | ||||||
LV end-diastolic volume (mL) | 128 ± 16 | 109 ± 12 | ||||
LV end-systolic volume (mL) | 52 ± 10 | 38 ± 8 | ||||
LV stroke volume (mL) | 76 ± 12 | 72 ± 10 | ||||
LV ejection fraction (%) | 59 ± 6 | 66 ± 6 | ||||
LV mass (g) | 151 ± 27 | 95 ± 17 | ||||
RV end-diastolic volume (mL) | 97 ± 13* | 78 ± 5 | ||||
RV end-systolic volume (mL) | 53 ± 15 | 37 ± 4 | ||||
RV ejection fraction (%) | 47 ± 10 | 52 ± 6 | ||||
RV mass (g) | 82 ± 9 | 57 ± 6 | ||||
LV peak filling rate (mL/s) | 349 ± 114* | 514 ± 81 |