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Table 2 Serial measurements of the left and right ventricular systolic and diastolic parameters

From: Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension

Parameter Baseline 2 months FUP 3 months FUP 4 months FUP 5 months FUP
HYPI (n = 7) Control (n = 5) HYPI (n = 7) Control (n = 5) HYPI (n = 7) Control (n = 5) HYPI (n = 7) Control (n = 5) HYPI (n = 7) Control (n = 5)
Weight (kg) 15 ± 3 15 ± 1 34 ± 4 34 ± 3 53 ± 8 53 ± 5 74 ± 8 74 ± 4 93 ± 9 94 ± 7
TTE
 LA diameter (mm) 26 ± 2 25 ± 2 29 ± 3 28 ± 2 31 ± 2 29 ± 2 42 ± 2* 30 ± 2 45 ± 3* 34 ± 3
 E/A ratio 1.2 ± 0.2 1.3 ± 0.3 1.1 ± 0.1 1.2 ± 0.2 1.0 ± 0.1 1.2 ± 0.3 0.9 ± 0.1* 1.2 ± 0.1 0.9 ± 0.6* 1.2 ± 0.2
 E/e′ ratio 5.4 ± 0.2 4.8 ± 2.1 6.3 ± 0.8 5.3 ± 0.7 6.5 ± 1.1 5.2 ± 1.1 8.8 ± 0.5* 4.9 ± 0.6 9.2 ± 1.5* 5.4 ± 2.2
 Mean circumferential end-diastolic wall thickness (mm) 11.1 ± 0.9 11.1 ± 0.8 12.7 ± 1.9 11.2 ± 1.1 13.0 ± 1.2 10.9 ± 0.9 16.6 ± 1.7* 9.8 ± 1.1 19.4 ± 3.1* 11.4 ± 1.0
Invasive pressure measurements (pigtail)
 Heart rate (bpm) 93 ± 29 98 ± 29 93 ± 8 93 ± 12 110 ± 22 92 ± 18 90 ± 11 87 ± 4 110 ± 19* 90 ± 20
 LV syst. pressure (mmHg) 112 ± 16 104 ± 20 140 ± 19 111 ± 11 151 ± 11* 110 ± 17 160 ± 6* 126 ± 6 167 ± 15* 116 ± 23
 LV end-diastolic pressure (mmHg) 8 ± 8 7 ± 7 20 ± 6 8 ± 10 22 ± 10* 17 ± 4 22 ± 2* 7 ± 2 23 ± 14* 13 ± 5
 LV dP/dT (mmHg/s) 979 ± 150 1010 ± 329 1403 ± 431 1105 ± 370 1604 ± 388* 1061 ± 511 1597 ± 95* 1095 ± 75 1610 ± 416* 1186 ± 403
 Aorta asc. syst. pressure (mmHg) 110 ± 12 105 ± 23 134 ± 18 109 ± 28 141 ± 14* 100 ± 23 150 ± 6* 123 ± 5 155 ± 18* 108 ± 13
 Aorta asc. diast. pressure (mmHg) 72 ± 9 67 ± 15 78 ± 9 67 ± 13 79 ± 10 63 ± 11 94 ± 5 76 ± 4 95 ± 20* 70 ± 8
 Post-stent aorta desc. syst. Pressure (mmHg) 108 ± 13 108 ± 15 93 ± 6 108 ± 9 87 ± 13 110 ± 10 89 ± 2 119 ± 6 93 ± 14* 107 ± 10
 Post-stent aorta dessc. diast. pressure (mmHg) 69 ± 13 71 ± 16 57 ± 13 61 ± 9 57 ± 11 73 ± 6 64 ± 3 75 ± 6 74 ± 15* 69 ± 9
 Aorta transstenotic gradient (mmHg) 2 ± 2 2 ± 1 40 ± 15* 7 ± 14 51 ± 20* 4 ± 4 61 ± 7* 4 ± 3 64 ± 14* 1 ± 4
 RA pressure (mmHg) A valve 6 ± 6 5 ± 5 10 ± 7 10 ± 9 10 ± 7 10 ± 6 11 ± 2 6 ± 3 12 ± 9* 8 ± 5
 RA pressure (mmHg) V valve 5 ± 4 5 ± 5 10 ± 5 9 ± 4 16 ± 3 9 ± 6 11 ± 2 5 ± 2 12 ± 4* 7 ± 5
 RV syst. pressure (mmHg) 20 ± 8 18 ± 6 29 ± 11 21 ± 5 42 ± 7* 28 ± 4 47 ± 4* 23 ± 5 51 ± 5* 30 ± 4
 RV end-diast. Pressure (mmHg) 9 ± 4 10 ± 4 10 ± 2 9 ± 1 8 ± 4 5 ± 5 12 ± 2 5 ± 2 13 ± 5* 9 ± 4
 RV dP/dT (mmHg/min) 160 ± 43 172 ± 93 297 ± 108 175 ± 63 402 ± 40* 162 ± 58 425 ± 35 237 ± 37 473 ± 153* 273 ± 195
 Pulmonary artery systolic pressure (mmHg) 24 ± 6 25 ± 6 29 ± 12 21 ± 8 35 ± 15 25 ± 4 43 ± 4 22 ± 3 45 ± 5* 26 ± 6
 Pulmonary artery diastolic pressure (mmHg) 11 ± 1 12 ± 4 17 ± 8 10 ± 3 22 ± 10* 13 ± 2 25 ± 4* 11 ± 1 27 ± 6* 10 ± 2
 Pulmonary artery mean pressure (mmHg) 21 ± 2 18 ± 4 23 ± 10 16 ± 5 29 ± 12 19 ± 3 34 ± 4* 17 ± 2 36 ± 5* 18 ± 4
  1. Data were collected using transthoracal echocardiography (TTE), invasive pressure measurements (pigtail) in hypertrophic pigs (HYPI) and in controls
  2. Italics Parameters characterizing LV hypertrophy
  3. LV left ventricular, RA right atrial, RV right ventricular
  4. * p < 0.05 for TTE and p < 0.005 for invasive pressure measurements parameter (ANOVA after Bonferroni correction) between the groups at the same time point