Parameter | Baseline | 2 months FUP | 3 months FUP | 4 months FUP | 5 months FUP | |||||
---|---|---|---|---|---|---|---|---|---|---|
HYPI (n = 7) | Control (n = 5) | HYPI (n = 7) | Control (n = 5) | HYPI (n = 7) | Control (n = 5) | HYPI (n = 7) | Control (n = 5) | HYPI (n = 7) | Control (n = 5) | |
Weight (kg) | 15 ± 3 | 15 ± 1 | 34 ± 4 | 34 ± 3 | 53 ± 8 | 53 ± 5 | 74 ± 8 | 74 ± 4 | 93 ± 9 | 94 ± 7 |
TTE | ||||||||||
LA diameter (mm) | 26 ± 2 | 25 ± 2 | 29 ± 3 | 28 ± 2 | 31 ± 2 | 29 ± 2 | 42 ± 2* | 30 ± 2 | 45 ± 3* | 34 ± 3 |
E/A ratio | 1.2 ± 0.2 | 1.3 ± 0.3 | 1.1 ± 0.1 | 1.2 ± 0.2 | 1.0 ± 0.1 | 1.2 ± 0.3 | 0.9 ± 0.1* | 1.2 ± 0.1 | 0.9 ± 0.6* | 1.2 ± 0.2 |
E/e′ ratio | 5.4 ± 0.2 | 4.8 ± 2.1 | 6.3 ± 0.8 | 5.3 ± 0.7 | 6.5 ± 1.1 | 5.2 ± 1.1 | 8.8 ± 0.5* | 4.9 ± 0.6 | 9.2 ± 1.5* | 5.4 ± 2.2 |
Mean circumferential end-diastolic wall thickness (mm) | 11.1 ± 0.9 | 11.1 ± 0.8 | 12.7 ± 1.9 | 11.2 ± 1.1 | 13.0 ± 1.2 | 10.9 ± 0.9 | 16.6 ± 1.7* | 9.8 ± 1.1 | 19.4 ± 3.1* | 11.4 ± 1.0 |
Invasive pressure measurements (pigtail) | ||||||||||
Heart rate (bpm) | 93 ± 29 | 98 ± 29 | 93 ± 8 | 93 ± 12 | 110 ± 22 | 92 ± 18 | 90 ± 11 | 87 ± 4 | 110 ± 19* | 90 ± 20 |
LV syst. pressure (mmHg) | 112 ± 16 | 104 ± 20 | 140 ± 19 | 111 ± 11 | 151 ± 11* | 110 ± 17 | 160 ± 6* | 126 ± 6 | 167 ± 15* | 116 ± 23 |
LV end-diastolic pressure (mmHg) | 8 ± 8 | 7 ± 7 | 20 ± 6 | 8 ± 10 | 22 ± 10* | 17 ± 4 | 22 ± 2* | 7 ± 2 | 23 ± 14* | 13 ± 5 |
LV dP/dT (mmHg/s) | 979 ± 150 | 1010 ± 329 | 1403 ± 431 | 1105 ± 370 | 1604 ± 388* | 1061 ± 511 | 1597 ± 95* | 1095 ± 75 | 1610 ± 416* | 1186 ± 403 |
Aorta asc. syst. pressure (mmHg) | 110 ± 12 | 105 ± 23 | 134 ± 18 | 109 ± 28 | 141 ± 14* | 100 ± 23 | 150 ± 6* | 123 ± 5 | 155 ± 18* | 108 ± 13 |
Aorta asc. diast. pressure (mmHg) | 72 ± 9 | 67 ± 15 | 78 ± 9 | 67 ± 13 | 79 ± 10 | 63 ± 11 | 94 ± 5 | 76 ± 4 | 95 ± 20* | 70 ± 8 |
Post-stent aorta desc. syst. Pressure (mmHg) | 108 ± 13 | 108 ± 15 | 93 ± 6 | 108 ± 9 | 87 ± 13 | 110 ± 10 | 89 ± 2 | 119 ± 6 | 93 ± 14* | 107 ± 10 |
Post-stent aorta dessc. diast. pressure (mmHg) | 69 ± 13 | 71 ± 16 | 57 ± 13 | 61 ± 9 | 57 ± 11 | 73 ± 6 | 64 ± 3 | 75 ± 6 | 74 ± 15* | 69 ± 9 |
Aorta transstenotic gradient (mmHg) | 2 ± 2 | 2 ± 1 | 40 ± 15* | 7 ± 14 | 51 ± 20* | 4 ± 4 | 61 ± 7* | 4 ± 3 | 64 ± 14* | 1 ± 4 |
RA pressure (mmHg) A valve | 6 ± 6 | 5 ± 5 | 10 ± 7 | 10 ± 9 | 10 ± 7 | 10 ± 6 | 11 ± 2 | 6 ± 3 | 12 ± 9* | 8 ± 5 |
RA pressure (mmHg) V valve | 5 ± 4 | 5 ± 5 | 10 ± 5 | 9 ± 4 | 16 ± 3 | 9 ± 6 | 11 ± 2 | 5 ± 2 | 12 ± 4* | 7 ± 5 |
RV syst. pressure (mmHg) | 20 ± 8 | 18 ± 6 | 29 ± 11 | 21 ± 5 | 42 ± 7* | 28 ± 4 | 47 ± 4* | 23 ± 5 | 51 ± 5* | 30 ± 4 |
RV end-diast. Pressure (mmHg) | 9 ± 4 | 10 ± 4 | 10 ± 2 | 9 ± 1 | 8 ± 4 | 5 ± 5 | 12 ± 2 | 5 ± 2 | 13 ± 5* | 9 ± 4 |
RV dP/dT (mmHg/min) | 160 ± 43 | 172 ± 93 | 297 ± 108 | 175 ± 63 | 402 ± 40* | 162 ± 58 | 425 ± 35 | 237 ± 37 | 473 ± 153* | 273 ± 195 |
Pulmonary artery systolic pressure (mmHg) | 24 ± 6 | 25 ± 6 | 29 ± 12 | 21 ± 8 | 35 ± 15 | 25 ± 4 | 43 ± 4 | 22 ± 3 | 45 ± 5* | 26 ± 6 |
Pulmonary artery diastolic pressure (mmHg) | 11 ± 1 | 12 ± 4 | 17 ± 8 | 10 ± 3 | 22 ± 10* | 13 ± 2 | 25 ± 4* | 11 ± 1 | 27 ± 6* | 10 ± 2 |
Pulmonary artery mean pressure (mmHg) | 21 ± 2 | 18 ± 4 | 23 ± 10 | 16 ± 5 | 29 ± 12 | 19 ± 3 | 34 ± 4* | 17 ± 2 | 36 ± 5* | 18 ± 4 |