Fig. 3

Immunohistochemistry staining for SLFN11: A (IHC; 400×) Positive external control constituted by SKOV-3 cell block culture. B (IHC; 400×) Negative external control constituded by normal menopausal ovary: no stain in both overian surface cells and stromal cells. C (IHC, 400×) SLFN negative HGSC: cancer cells show no stain, TILs show an intense stain representing a useful internal control. D (IHC, 400×) SLFN low HGSC (HS 2) with a faint (IS 1 +) inconstant (DS 2 +) pattern of stain. E (IHC, 400×) SLFN intermediate HGSC (HS4) with a moderate (IS 2 +) inconstant (DS 2 +) pattern of stain. F (IHC, 400×) SLFN high HGSC (HS 6) with an intense (IS 3 +) but inconstant (DS 2 +) pattern of stain