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Table 2 Cytogenetic characteristics and gene expression level

From: Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance

Gene expression Cytogenetic characteristics, n (%) (failed = 15)
CBF-AML Cytogenetic intermediate-risk Cytogenetic high-risk
t(8;21) inv(16) Normal cytogenetics Others 11q23 Others
MECOM P < 0.001
 Low 34 (12.5) 9 (3.3) 181 (66.8) 34 (12.5) 5 (1.8) 8 (3.0)
 High 40 (15.3) 6 (2.3) 130 (49.6) 44 (16.8) 22 (8.4) 20 (7.6)
 P 0.364 0.472 <0.001 0.165 0.001 0.015
MEIS1 P < 0.001
 Low 72 (26.6) 1 (0.4) 152 (56.1) 30 (11.1) 6 (2.2) 10 (3.7)
 High 2 (0.7) 14 (5.1) 168 (61.3) 51 (18.6) 21 (7.7) 18 (6.6)
 P <0.001 0.001 0.215 0.013 0.003 0.128
SPI1 P < 0.001
 Low 34 (12.5) 0 (0.0) 172 (63.2) 46 (16.9) 8 (2.9) 12 (4.4)
 High 40 (14.7) 15 (5.5) 148 (54.2) 35 (12.8) 19 (7.0) 16 (5.9)
 P 0.463 <0.001 0.032 0.179 0.031 0.444
ERG P = 0.004
 Low 28 (10.4) 5 (1.9) 160 (59.5) 54 (20.1) 11 (4.1) 11 (4.1)
 High 46 (16.7) 10 (3.6) 160 (58.0) 27 (9.8) 16 (5.8) 17 (6.2)
 P 0.033 0.208 0.721 0.001 0.358 0.274
WT1 P < 0.001
 Low 55 (20.4) 0 (0.0) 152 (56.3) 41 (15.2) 8 (3.0) 14 (5.2)
 High 19 (7.0) 15 (5.5) 166 (60.8) 40 (14.7) 19 (7.0) 14 (5.1)
 P <0.001 <0.001 0.286 0.862 0.032 0.976
GATA2 P = 0.082
 Low 46 (17.0) 10 (3.7) 145 (53.5) 44 (16.2) 12 (4.4) 14 (5.2)
 High 28 (10.2) 5 (1.8) 175 (63.9) 37 (13.5) 15 (5.5) 14 (5.1)
 P 0.021 0.183 0.014 0.370 0.574 0.976
BAALC P < 0.001
 Low 9 (3.3) 0 (0.0) 180 (66.7) 48 (17.8) 21 (7.8) 12 (4.4)
 High 65 (23.6) 15 (5.5) 140 (50.9) 33 (12.0) 6 (2.2) 16 (5.8)
 P <0.001 <0.001 <0.001 0.058 0.003 0.468