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Table 2 Cytogenetic characteristics and gene expression level

From: Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance

Gene expression

Cytogenetic characteristics, n (%) (failed = 15)

CBF-AML

Cytogenetic intermediate-risk

Cytogenetic high-risk

t(8;21)

inv(16)

Normal cytogenetics

Others

11q23

Others

MECOM

P < 0.001

 Low

34 (12.5)

9 (3.3)

181 (66.8)

34 (12.5)

5 (1.8)

8 (3.0)

 High

40 (15.3)

6 (2.3)

130 (49.6)

44 (16.8)

22 (8.4)

20 (7.6)

 P

0.364

0.472

<0.001

0.165

0.001

0.015

MEIS1

P < 0.001

 Low

72 (26.6)

1 (0.4)

152 (56.1)

30 (11.1)

6 (2.2)

10 (3.7)

 High

2 (0.7)

14 (5.1)

168 (61.3)

51 (18.6)

21 (7.7)

18 (6.6)

 P

<0.001

0.001

0.215

0.013

0.003

0.128

SPI1

P < 0.001

 Low

34 (12.5)

0 (0.0)

172 (63.2)

46 (16.9)

8 (2.9)

12 (4.4)

 High

40 (14.7)

15 (5.5)

148 (54.2)

35 (12.8)

19 (7.0)

16 (5.9)

 P

0.463

<0.001

0.032

0.179

0.031

0.444

ERG

P = 0.004

 Low

28 (10.4)

5 (1.9)

160 (59.5)

54 (20.1)

11 (4.1)

11 (4.1)

 High

46 (16.7)

10 (3.6)

160 (58.0)

27 (9.8)

16 (5.8)

17 (6.2)

 P

0.033

0.208

0.721

0.001

0.358

0.274

WT1

P < 0.001

 Low

55 (20.4)

0 (0.0)

152 (56.3)

41 (15.2)

8 (3.0)

14 (5.2)

 High

19 (7.0)

15 (5.5)

166 (60.8)

40 (14.7)

19 (7.0)

14 (5.1)

 P

<0.001

<0.001

0.286

0.862

0.032

0.976

GATA2

P = 0.082

 Low

46 (17.0)

10 (3.7)

145 (53.5)

44 (16.2)

12 (4.4)

14 (5.2)

 High

28 (10.2)

5 (1.8)

175 (63.9)

37 (13.5)

15 (5.5)

14 (5.1)

 P

0.021

0.183

0.014

0.370

0.574

0.976

BAALC

P < 0.001

 Low

9 (3.3)

0 (0.0)

180 (66.7)

48 (17.8)

21 (7.8)

12 (4.4)

 High

65 (23.6)

15 (5.5)

140 (50.9)

33 (12.0)

6 (2.2)

16 (5.8)

 P

<0.001

<0.001

<0.001

0.058

0.003

0.468