Set

Parameters

Characteristics



R
^{a}_{0max}

R
^{a}_{0min}

RF
^{b}_{
Z
}

CC
^{c}_{
Y
}

I
_{
Y peak} (day)^{d}

I
_{
Z peak} (day)^{e}

I
_{
Z max}/I
^{f}_{
Y max}

I
_{
Y
}*I
_{
Z
} (day)^{g}

Correlation coefficient (%)

R
^{h}_{eZ
}

R
^{i}_{eY\Z
}


1

2.00

1.61

1.00

0.71

167

307

21.93

210

96.96

1.65

0.75

2

2.00

1.61

1.00

0.72

167

307

21.95

209

96.96

1.65

0.75

3

2.00

1.61

1.00

0.73

167

307

21.98

209

96.95

1.65

0.75

4

2.01

1.61

1.00

0.67

167

307

21.81

213

96.95

1.65

0.75

5

2.00

1.61

1.00

0.74

167

307

22.00

208

96.95

1.65

0.75

6

2.01

1.61

1.00

0.68

167

307

21.84

213

96.94

1.65

0.75

7

2.00

1.61

1.00

0.75

167

307

22.02

207

96.94

1.65

0.75

8

2.01

1.61

1.00

0.69

167

307

21.87

212

96.94

1.65

0.75

9

2.01

1.61

1.00

0.70

167

307

21.90

211

96.93

1.65

0.75

10

2.01

1.61

1.00

0.71

167

307

21.93

210

96.92

1.65

0.75

GM
         
1.65

0.75

GSD
         
1.00

1.00

 13965 simulations were performed with the parameters R
_{0max}, R
_{0min}, RF
_{
Z
}, and CC
_{
Y
} set within each specified range. 10 bestfit simulations were selected based on the correlation coefficient between the simulated epidemic curve and the observed weekly A/H1N1 IVIR curve. Pearson method was used to estimate the correlation coefficient

GM geometric mean, GSD geometric standard deviation

^{a}
R
_{0max} and R
_{0min} defined the range of the basic reproductive number [25]

^{b}
RF
_{
Z
} represented relative fitness of clade Z

^{c}
CC
_{
Y
} represented competition cost of clade Y

^{d}
I
_{
Ypeak} denoted the peak day of clade Y epidemic which was manifested by the infectives of clade Y

^{e}
I
_{
Zpeak} denoted the peak day of clade Z epidemic which was manifested by the infectives of clade Z

^{f}
I
_{
Zmax
}
/I
_{
Ymax
} denoted the height ratio of clade Z epidemic to clade Y epidemic

^{g}
I
_{
Y
}*I
_{
Z
} denoted the crossing day of clade Z epidemic with clade Y epidemic

^{h}
R
_{eZ
} estimated the annual effective reproductive number of clade Z

^{i}
ReY\Z estimated the annual effective reproductive number of clade Y in the presence of clade Z