Table 4 Univariate and multivariate analysis according to the various criteria
Factors | Univariate analysis | P |
|---|---|---|
Age | 1.022 (1.033–1.042) | 0.021 |
Sex | 0.823 (0.545–1.245) | 0.357 |
Tumor size | 1.150 (1.058–1.251) | 0.001 |
Histologic grade (high vs. low) | 3.582 (2.136–6.007) | <0.001 |
Tumor border (infiltrative vs. expanding) | 4.173 (1.532–11.365) | 0.005 |
Lymphatic invasion (present vs. absent) | 3.345 (2.039–5.488) | <0.001 |
Venous invasion (present vs. absent) | 3.777 (2.484–5.741) | <0.001 |
Neural invasion (present vs. absent) | 3.601 (2.389–5.427) | <0.001 |
pTNM stage (IV vs. I–III) | 7.727 (5.109–11.687) | <0.001 |
Amplification in any gene (≥2 vs. <2) | 1.235 (0.759–2.008) | 0.395 |
GCN gain in any gene (≥4 vs. <4) | 1.770 (1.175–2.666) | 0.006 |
ASCO/CAP criteria in any gene (positive/equivocal vs. negative) | 1.608 (1.067–2.421) | 0.023 |
Factors | Multivariate analysis | P |
|---|---|---|
GCN gain | ||
Age | 1.038 (1.015–1.061) | 0.001 |
Sex | 0.643 (0.414–0.999) | 0.049 |
Tumor size | 1.115 (1.001–1.243) | 0.048 |
Histologic grade (high vs. low) | 2.843 (1.571–5.143) | 0.001 |
Tumor border (infiltrative vs. expanding) | 2.550 (0.899–7.231) | 0.078 |
Lymphatic invasion (present vs. absent) | 1.296 (0.737–2.276) | 0.368 |
Venous invasion (present vs. absent) | 1.197 (0.720–1.989) | 0.489 |
Neural invasion (present vs. absent) | 2.400 (1.506–3.827) | <0.001 |
pTNM stage (IV vs. I–III) | 4.791 (2.891–7.940) | <0.001 |
GCN gain in any gene (≥4 vs. <4) | 1.750 (1.145–2.673) | 0.010 |
ASCO/CAP criteria | ||
Age | 1.038 (1.016–1.061) | 0.001 |
Sex | 0.645 (0.415–1.003) | 0.052 |
Tumor size | 1.114 (0.999–1.241) | 0.052 |
Histologic grade (high vs. low) | 2.857 (1.578–5.174) | 0.001 |
Tumor border (infiltrative vs. expanding) | 2.525 (0.891–7.155) | 0.081 |
Lymphatic invasion (present vs. absent) | 1.289 (0.734–2.265) | 0.377 |
Venous invasion (present vs. absent) | 1.197 (0.721–1.987) | 0.488 |
Neural invasion (present vs. absent) | 2.414 (1.514–3.850) | <0.001 |
pTNM stage (IV vs. I–III) | 4.868 (2.941–8.057) | <0.001 |
ASCO/CAP criteria in any gene (positive/equivocal vs. negative) | 1.676 (1.097–2.561) | 0.017 |