Skip to main content

Table 4 Results for re-implantation of cryopreserved tumors

From: Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis

Case

Pre-implanted tumor

Cryo-medium

Cryopreserved days

Engraftment

Post-implanted tumor

Generation

Pigment

Ki67% positive cells (%)

Generation

Tumor take rate (mouse)

Volume (mm3)

Pigment

Ki67% positive cells (%)

2

X1

None

20.1

Fresh

None

Success

X2

1/1

958.9

None

17.0

F

30

Success

1/1

189.2

None

15.4

D

Success

1/1

364.1

None

15.0

R

Success

1/1

103.5

None

14.9

5

X1

None

24.6

Fresh

None

Success

X2

1/1

1258.0

None

22.8

F

15

Success

1/1

128.3

None

14.2

D

Success

1/1

635.1

None

19.8

R

Success

1/1

254.3

None

17.3

7

X1

Minimal

16.1

Fresh

 

Success

X2

1/1

365.1

Minimal

15.9

F

15

Failure

0/1

–

–

–

D

Success

1/1

5.5

Minimal

15.4

R

Success

1/1

0.32

Minimal

15.7

12

X1

Moderate

18.3

Fresh

None

Success

X2

1/1

998.5

Moderate

20.4

F

15

Success

1/1

92.34

Moderate

15.6

D

Success

1/1

686.7

Moderate

16.9

R

Success

1/1

502.1

Moderate

15.2

  1. X 0  patient’s tumor; X 1  first-generation mice, X 2  second-generation mice, fresh direct implantation without cryopreservation, F F medium (90% fetal bovine serum/10% DMSO), D D medium (70% DMEM/20% fetal bovine serum/10% DMSO), R R medium (70% RPMI/20% fetal bovine serum/10% DMSO)