Table 1 Rate and specificities of the breast cancer molecular subtypes
From: Precision medicine in breast cancer: reality or utopia?
Subtypes | Frequency | Gene expression | Histologic grade level | Prognosis |
|---|---|---|---|---|
Luminal | 60% BC | Â | Â | Â |
 Luminal A |  | ER+, PR+, HER− | Low | Good |
 Luminal B |  | Low p53 mutation ER+, PR+, HER2++ | High | Less favorable |
Basal-like (TN) | 15–20% | ER−, PR−, HER− | Often grade III | Poor (chemosensitive) |
HER2+ | 25% | HER2++ | High | More aggressive (anti-HER2 sensitive) |