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Table 2 Descriptive data

From: Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

 

Group

Min

Max

Average

Median

IQR

SD

Hematoxylin and eosin (H&E) staining

 Diameter of osteoclasts (µm)

MRONJ (BP)

22.3

54.4

35.7

35.2

11.3

7.6

OM

15.1

35.6

25.5

25.4

7.2

5.4

ORN

15.8

43.0

25.3

23.7

12.7

8.1

CONTROL

19.3

25.6

22.3

22.0

3.1

2.0

 Nuclearity of osteoclasts (nuclei/osteoclast)

MRONJ (BP)

3.6

7.1

4.8

4.6

1.5

1.0

OM

2.2

3.7

2.7

2.6

0.7

0.4

ORN

2.0

3.8

2.6

2.4

0.9

0.6

CONTROL

2.0

3.0

2.5

2.6

0.5

0.3

 Osteoclasts per ROI (osteoclasts/mm2)

MRONJ (BP)

2.3

110.0

38.9

29.7

32.6

27.7

OM

7.3

32.5

20.0

20.2

12.0

7.3

ORN

2.3

60.1

16.0

7.8

6.9

18.4

CONTROL

4.4

47.9

14.0

9.5

10.8

13.2

TRAP staining

 TRAP+ osteoclasts per ROI (osteoclasts/mm2)

MRONJ (BP)

0.0

59.8

8.3

0.0

0.9

18.7

OM

0.0

125.4

44.3

47.7

69.6

39.0

ORN

0.0

83.9

7.5

0.0

1.5

21.8

CONTROL

0.0

91.1

25.6

10.1

53.5

32.6

 Labeling index (%/100)

MRONJ (BP)

0

1

0.176

0

0.077

0.357

OM

0

1

0.687

1

1

0.464

ORN

0

1

0.231

0

0.180

0.403

CONTROL

0

1

0.686

1

1

0.476

Anti-DC-STAMP staining

 Positive cells per ROI (cells/mm2)

MRONJ (BP)

38.3

636.8

266.6

236.6

146.9

147.2

OM

0.0

235.1

61.1

0.0

102.9

79.8

ORN

127.1

716.7

327.7

272.1

187.3

174.3

CONTROL

0.0

71.8

7.2

0.0

0.0

22.7

 DC-STAMP+ osteoclasts per ROI (osteoclasts/mm2)

MRONJ (BP)

0.0

34.5

10.9

8.9

12.4

9.6

OM

0.0

6.3

1.3

0.0

2.6

1.9

ORN

0.0

8.6

3.1

2.3

3.6

2.3

CONTROL

0.0

2.1

0.2

0.0

0.0

0.6

 Labeling index (%/100)

MRONJ (BP)

0

1

0.331

0.279

0.290

0.254

OM

0

0.290

0.066

0

0.150

0.093

ORN

0

1

0.375

0.342

0.650

0.333

CONTROL

0

0.083

0.008

0

0

0.026

Analysis within MRONJ (BP) group

 Diameter of osteoclasts (µm)

DC-STAMP+ OCs

13.8

29.2

22.3

22.5

6.4

4.0

Average OCs (H&E)

22.3

54.4

35.7

35.2

11.3

7.6

 Nuclearity of osteoclasts (nuclei/osteoclast)

DC-STAMP+ OCs

2.0

3.4

2.5

2.5

0.4

0.4

Average OCs (H&E)

3.6

7.01

4.8

4.6

1.0

1.0

  1. Min, minimum; Max, maximum; IQR, interquartile range; SD, standard deviation; H&E, hematoxylin and eosin stain; MRONJ (BP), medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy; OM, osteomyelitis; ORN, osteoradionecrosis; DC-STAMP, dendritic cell-specific transmembrane protein; TRAP, tartrate-resistant acid phosphatase; MRONJ (BP), medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy; OC, osteoclasts; OM, osteomyelitis; ORN, osteoradionecrosis; DC-STAMP, dendritic cell-specific transmembrane protein; TRAP, tartrate-resistant acid phosphatase
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Journal of Translational Medicine

ISSN: 1479-5876

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