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Table 1 Patient data

From: Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

 

MRONJ (BP)

OM

ORN

CONTROL

Number of patients

30

15

15

10

Sex

53.3% women (16)

53.3% women (8)

13.3% women (2)

40% women (4)

Age (years)

Ø 67.8 ± 8.89

Ø 43.6 ± 25.20

Ø 57 ± 7.89

Ø 33.8 ± 16.17

(Primary) diagnosis

33.33% prostate cancer (10), 30% breast cancer (9), 20% multiple myeloma (6),10% osteoporosis (3), 0.33% renal cell carcinoma (1), 0.33% vertebral sclerosis (1)

86.6% chronic osteomyelitis (13), 13.3% acute osteomyelitis (2)

60% SCC oral cavity (9), 13.3% SCC oropharynx (2), 6.6% SCC hypopharynx (1), 6.6% SCC tonsil (1), 6.6% SCC cranial skin (1), 6.6% CUP

50% facial fracture (5), 20% dysgnathia (2), 10% cleft lip and palate (1), 10% wisdom tooth extraction (1), 10% arch ratio anomaly (1)

Extraction location

76.7% lower jaw (23), 23.3% upper jaw (7)

100% lower jaw (15)

100% lower jaw (15)

80% lower jaw (8), 20% upper jaw (2)

Additional information

100% nitrogenous. BPs (30): 70% zoledronate (21), 13.3% alendronate (4), 6.6% risedronate (2), 6.6% ibandronate (2), 3.3% pamidronate (1)

 

Ø total reference dose in the mandibular region: 68 Gy

(The applicated dose was set individually by the radiotherapists)

 
  1. Age is shown as the mean and standard deviation
  2. Ø, average; min, minimum; max, maximum; BP, bisphosphonate; MRONJ (BP), medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy; OM, osteomyelitis; ORN, osteoradionecrosis; SCC, squamous cell carcinoma; CUP, cancer of unknown primary