Fig. 4
From: Non-caloric sweetener provides magnetic resonance imaging contrast for cancer detection
SucCEST map of a rat brain glioma. a sucCEST contrast map from a rat with glioma shows increased contrast in tumor region following intravenous injection of sucralose with the sucCEST contrast peaking at 30 min post injection. b The kinetics showing the average percentage change from the baseline in the sucCEST contrast from tumor rats at different time points, which peaks ~30 min post end of infusion. c MTRasym curves generated from tumor ROI at baseline and post 30 min following the end of sucralose infusion show increased contrast at 1 ppm. d The normal brain, no signal change at 1 ppm post 30 min was observed in the MTRasym curve