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Table 1 Study population: inclusion and exclusion criteria

From: Blood metabolomic fingerprint is distinct in healthy coronary and in stenosing or microvascular ischemic heart disease

Inclusion criteria

Exclusion criteria

Case groups

 Age >18 years

 Stable Angina diagnosed in accordance with ESC guidelines

 Stress test positive for ischemia

Recent PTCA (1 month for BMS, 1 year for DES)

Inheritable metabolic disorders

Malignancies

Autoimmune diseases

Hepatic (transaminases ≥2 the upper limits of normal) or renal (creatinine ≥2.0 mg/dL) dysfunction

Control groups

 Age >18 years

 Indications for coronary angiography different from angina/myocardial infarction

Previous or present diagnosis of CAD

Coronary, carotid or peripheral arteries ATS

Moderate/severe hypertension or hypertension-induced organ damage (i.e. Left ventricular hypertrophy)

Inheritable metabolic disorders

Malignancies

Autoimmune diseases

Hepatic (transaminases ≥2 the upper limits of normal) or renal (creatinine ≥2.0 mg/dL) dysfunction