Skip to main content

Table 2 Significantly expressed miRNAs in the atrial myocardial tissue of patients with CHD after CPB (n = 3) compared to before CPB (n = 3) as determined by microarray

From: Differential expression of microRNAs following cardiopulmonary bypass in children with congenital heart diseases

miRNA

Median before CPB

Median after CPB

STDV before CPB

STDV after CPB

Fold change

Regulation

P-value

miR-4750-5p

1.67

8.60

2.59

4.24

5.26

Up

0.0399

miR-6134

1.00

3.08

0.46

0.78

3.03

Up

0.0215

miR-6873-3p

2.49

6.29

0.29

1.31

2.50

Up

0.0441

miR-4747-5p

1.07

2.38

0.78

1.05

2.22

Up

0.0151

miR-5195-5p

1.48

3.04

0.49

0.91

2.04

Up

0.0213

miR-6074

1.50

3.00

1.14

1.52

2.00

Up

0.0252

miR-6751-3p

2.89

5.68

0.33

1.12

1.96

Up

0.0323

miR-328-5p

15.50

28.90

4.82

3.56

1.85

Up

0.0263

miR-6792-5p

2.42

4.40

0.56

1.34

1.82

Up

0.0485

miR-4514

1.65

2.93

0.80

0.61

1.79

Up

0.0333

miR-4538

3.31

5.83

1.60

1.37

1.75

Up

0.0033

miR-6870-5p

2.31

3.91

1.63

1.88

1.69

Up

0.0102

miR-7156-5p

1.25

2.12

0.61

0.61

1.69

Up

0.0300

miR-4447

1.64

2.73

0.44

0.19

1.67

Up

0.0369

miR-6769b-5p

20.56

33.29

3.95

4.51

1.61

Up

0.0442

miR-7846-3p

5.11

8.12

1.69

2.65

1.59

Up

0.0398

miR-1261

1.90

2.98

1.58

2.01

1.56

Up

0.0353

miR-6740-5p

39.53

61.77

6.38

14.38

1.56

Up

0.0489

miR-6746-5p

3.75

5.79

1.03

1.20

1.54

Up

0.0265

miR-645

1.56

2.42

0.93

0.70

1.54

Up

0.0455

miR-2113

1.46

2.20

0.47

0.74

1.52

Up

0.0437

miR-497-3p

1.46

2.14

0.29

0.51

1.47

Up

0.0280

miR-648

1.64

2.39

0.55

0.44

1.47

Up

0.0497

miR-5088-5p

9.24

13.26

1.59

2.19

1.43

Up

0.0379

miR-3945

3.43

4.81

0.97

0.98

1.41

Up

0.0342

miR-4468

2.07

2.84

0.55

0.62

1.37

Up

0.0289

miR-1471

6.69

9.07

2.16

2.11

1.35

Up

0.0464

miR-5006-5p

21.99

28.90

2.45

3.83

1.32

Up

0.0108

miR-198

3.59

4.49

1.04

1.32

1.25

Up

0.0404

miR-770-5p

9.59

3.17

1.11

1.81

3.03

Down

0.0095

miR-4261

35.83

14.45

1.98

7.10

2.48

Down

0.0183

miR-874-5p

15.30

6.57

1.76

3.12

2.33

Down

0.0102

miR-550a-5p

5.57

2.44

1.67

1.10

2.29

Down

0.0114

miR-3651

53.15

23.24

5.23

9.24

2.29

Down

0.0455

miR-6865-3p

8.00

3.55

1.51

1.76

2.26

Down

0.0108

miR-222-3p

14.15

6.51

1.03

2.80

2.17

Down

0.0308

miR-3607-3p

8.69

4.10

0.70

1.25

2.12

Down

0.0424

miR-1304-3p

9.97

4.71

1.98

0.36

2.12

Down

0.0469

miR-6508-5p

9.27

4.41

2.31

1.58

2.10

Down

0.0358

miR-6800-3p

10.18

5.06

2.12

2.07

2.01

Down

0.0182

miR-6861-3p

6.13

3.09

0.74

0.86

1.99

Down

0.0139

miR-212-3p

25.83

13.01

2.76

6.93

1.99

Down

0.0294

miR-6737-3p

11.31

5.76

2.96

1.67

1.96

Down

0.0293

miR-6820-5p

37.19

19.53

0.20

4.42

1.90

Down

0.0238

miR-6792-3p

6.60

3.47

1.06

1.47

1.90

Down

0.0366

miR-3616-3p

6.92

3.68

1.31

1.75

1.88

Down

0.0082

miR-3162-3p

10.75

5.79

2.89

2.53

1.86

Down

0.0029

miR-423-3p

9.21

4.94

1.09

1.21

1.86

Down

0.0056

miR-5190

10.43

5.68

0.59

0.86

1.84

Down

0.0172

miR-4725-5p

8.95

4.90

1.35

2.34

1.83

Down

0.0421

miR-744-5p

9.67

5.32

1.56

1.98

1.82

Down

0.0308

miR-6829-5p

48.68

26.75

3.55

8.52

1.82

Down

0.0360

miR-6889-3p

8.18

4.51

1.73

1.02

1.82

Down

0.0432

miR-4433a-5p

8.38

4.62

2.04

1.02

1.81

Down

0.0276

miR-6813-3p

7.19

4.06

2.29

1.01

1.77

Down

0.0343

miR-4649-3p

9.50

5.47

3.12

2.42

1.74

Down

0.0093

miR-6763-3p

7.94

4.62

1.52

1.52

1.72

Down

0.0434

miR-532-3p

18.58

10.78

0.43

3.99

1.72

Down

0.0487

miR-6769a-5p

11.01

6.45

1.97

1.02

1.71

Down

0.0219

miR-193b-3p

74.91

43.92

26.81

34.56

1.71

Down

0.0341

miR-331-5p

2.64

1.58

0.28

0.62

1.67

Down

0.0446

miR-6858-3p

8.53

5.15

2.59

2.47

1.66

Down

0.0017

miR-564

17.68

10.75

2.27

3.32

1.65

Down

0.0099

miR-6723-5p

26.08

16.14

2.83

6.35

1.62

Down

0.0352

miR-28-3p

4.85

3.02

0.21

0.58

1.61

Down

0.0187

miR-339-3p

13.22

8.22

1.98

2.36

1.61

Down

0.0275

miR-23c

5.83

3.62

1.59

0.81

1.61

Down

0.0378

miR-93-5p

114.26

70.98

9.72

24.81

1.61

Down

0.0488

miR-6752-3p

5.76

3.67

1.11

0.79

1.57

Down

0.0329

miR-766-3p

10.39

6.64

1.38

2.07

1.56

Down

0.0125

miR-1306-5p

4.68

3.05

0.44

0.67

1.54

Down

0.0074

miR-6798-3p

4.49

2.92

0.87

1.04

1.54

Down

0.0141

miR-664a-3p

17.21

11.20

1.39

3.72

1.54

Down

0.0362

miR-208a-5p

45.35

29.37

7.47

13.45

1.54

Down

0.0450

miR-6880-3p

6.55

4.43

2.43

1.74

1.48

Down

0.0272

miR-143-3p

327.88

223.74

43.81

69.68

1.47

Down

0.0425

miR-624-5p

3.66

2.49

0.37

0.53

1.47

Down

0.0447

miR-210-5p

4.05

2.86

0.41

0.39

1.42

Down

0.0101

miR-6073

5.18

3.67

1.17

1.43

1.41

Down

0.0140

miR-374c-5p

11.99

8.54

1.55

2.75

1.40

Down

0.0378

miR-4484

27.73

20.62

1.81

1.80

1.34

Down

0.0000

miR-4664-3p

5.01

3.75

0.50

0.61

1.34

Down

0.0096

miR-6731-3p

4.38

3.26

1.21

1.48

1.34

Down

0.0399

miR-4769-3p

6.46

5.11

1.50

1.35

1.26

Down

0.0213

miR-15a-3p

3.49

2.79

0.34

0.28

1.25

Down

0.0114

hsa-let-7a-3p

3.24

2.59

0.35

0.29

1.25

Down

0.0172

miR-26b-3p

3.15

2.54

0.72

0.55

1.24

Down

0.0244

miR-940

32.01

26.08

7.78

6.20

1.23

Down

0.0218

miR-3189-3p

3.61

3.01

0.44

0.33

1.20

Down

0.0153

miR-29a-5p

3.05

2.53

0.16

0.28

1.20

Down

0.0166

  1. Each value represents the median of three patients before and after CBP and ±standard deviation (STDV). Statistical analysis was performed with paired-two-tailed t-test (P < 0.05)
Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us