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Table 2 Results of histopathological findings estimated for the total semiquantitative score

From: Experimental approach to IGF-1 therapy in CCl4-induced acute liver damage in healthy controls and mice with partial IGF-1 deficiency

Experimental group

Oxidative damage (0–2)

Lymphocytic infiltrate (0–1)

Fibrosis (0–2)

Steatosis

(0–1)

Cellular changes

(0–4)

Total score

(0–10)

Wt

0.08 ± 0.03

0.05 ± 0.03

0.10 ± 0.04

0.10 ± 0.00

0.68 ± 0.13

1.00 ± 0.10

Wt + CCl4

1.30 ± 0.09*

0.53 ± 0.04*

1.20 ± 0.04*

0.73 ± 0.04*

3.26 ± 0.10*

7.01 ± 0.16**

Wt + CCl4 + IGF-1

0.75 ± 0.03*&

0.65 ± 0.10*

0.38 ± 0.05*&

0.73 ± 0.05*

2.18 ± 0.10*&

4.68 ± 0.08*&

Hz

0.38 ± 0.04*

0.16 ± 0.02

0.20 ± 0.03

0.14 ± 0.02

2.78 ± 0.14*

3.66 ± 0.29*

Hz + CCl4

1.60 ± 0.04

0.78 ± 0.03

1.40 ± 0.04#

0.73 ± 0.03#

3.50 ± 0.21#

8.00 ± 0.17##£

Hz + CCl4 + IGF-1

0.73 ± 0.03##$$

0.60 ± 0.05##$

0.35 ± 0.04#$$

0.78 ± 0.03##

2.52 ± 0.19$$

4.98 ± 0.25#$

  1. * p < 0.05 vs Wt; ** p < 0.01 vs Wt; &p < 0.05 vs Wt + CCl4; #p < 0.05 vs Hz; ##p < 0.01 vs Hz; $p < 0.05, $$p < 0.01 vs Hz + CCl4; £p < 0.05 vs Wt + CCl4