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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Fig. 3

PBMCs were evaluated for the presence of granulocytic MDSCs (CD11b+CD14-CD33+HLA-DR−) at different time points post treatment initiation (a, b) and correlated to overall survival (c Pre, d Post, e fold change) or Tregs (CD3+CD4+FoxP3+CD127−) (f) using Spearmans test for nonparametric samples. Open circles in a and b indicates Responding patients, as determined by having decreased activity in tumor lesions as defined by PET/CT. g The ratio of Teff/gMDSC was calculated before and at 3 weeks post treatment initiation. Significant difference was calculated using Wilcoxon testing for paired samples. GraphPad Pris was used for statistical calculations

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Journal of Translational Medicine

ISSN: 1479-5876

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