Fig. 1
Effect of Ex-4, ADSCs, or a combination of Ex-4 and ADSCs on diabetic wound healing. Diabetic db/db mice (a, b) or normal C57BL/6 mice (c, d) were subjected to wounding (6 mm in diameter) by punch biopsy on the skin of the back. One day later, each wound received 2.5 × 105 ADSCs injected intradermally around the wound and/or 50 μl of 100 nM Ex-4 was applied to the wound with a fine brush, daily. a Changes of wound area at each of the time points compared with the original wound area. Values represent mean ± SEM. *p < 0.05 vs vehicle, $ p < 0.05 vs ADSC, # p < 0.05 vs EX-4. b Wound shapes were recorded over 14 days. c Wound area up to 4 days after artificial wound creation. *p < 0.05 vs vehicle, $ p < 0.05 vs ADSC, # p < 0.05 vs EX-4. d Wound shapes 2 and 4 days after artificial wound creation