Fig. 4

Immunohistochemical analysis of BMP2/4-7 expression. a Graph display the number of BMP2/4-7 muscle fibers in OA, OP and CTRL patients. b Image shows a muscle biopsy of OA patient with numerous BMP-2 positive fibers (4×). c Rare BMP-2 positive fibers in a muscle tissue of OP patient (4×). d Numerous BMP-2 positive fibers in a muscle biopsy of CTRL patient (4×). e Immunohistochemical reaction shows several BMP-4 positive fiber in a muscle biopsy of OA patient (4×). f Image shows a muscle biopsy of OP patient with rare/no BMP-4 positive fibers (4×). g Muscle of a CTRL patient characterize by high expression of BMP4 (4×). h Several BMP-7 positive fibers in a muscle tissue of OA patient (4×). i Immunohistochemical reaction shows no/rare BMP-7 positive fiber in a muscle biopsy of OP patient (4×). j, d Numerous BMP-7 positive fibers in a muscle biopsy of CTRL patient (4×)