Fig. 9

Gene signature of circulating Tr1 cells of two kidney transplant recipients is transiently affected by immmunosuppression. Percentages of Tr1 cells before (4 weeks pre-transplant) and after kidney transplantation (8, 36, 60 weeks) are shown. One line represents one patient (a). Percentages of circulating CD4⁺CD45RA⁻ T memory cells (within CD3⁺ T cells) in the two patients are shown (b). Transcript analysis of the indicated genes was performed on purified circulating Tr1 cells from patient #003 and #004. Bubble chart represents the gene expression signals for each patient over time: 4 weeks pre-transplant, 8-, 36- and 60-weeks post-transplant (normalized to housekeeping gene hprt1). Bubble size represents gene expression signal. Gene symbols are represented on the right (c)