Fig. 5From: Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppressionT10 cells are enriched in Tr1 cells. One representative flow cytometry staining (out of eight) of CD49b+LAG-3+ cells gated on CD4+CD45RA− of CD4+ T cells, control Tm cells and T10 cells is shown (upper panel a). Percentages of CD49b+LAG-3+ (within CD4+CD45RA−) Tr1 cells are shown. Each closed square represents one experiment with buffy coats from healthy donors; each open square represents one experiment with leukapheresis from patients on dialysis. Lines represent mean value of each data set ± SD (lower panel a). Percentages of Tr1 cells in the starting CD4+ T cells are plotted against percentages of Tr1 cells within the corresponding T10 cells. One dot represents one experiment. Line represents linear regression (b)Back to article page