Table 4 Mutations in PDX models used for in vivo therapy experiments
From: Optimized creation of glioblastoma patient derived xenografts for use in preclinical studies
Sample ID | Mutations in PDX |
|---|---|
HROG05 | EGFR (R108K, Y626H), K-Ras (G12D), P53 (R280K) |
HROG07 | APC (A1340 V), FLT3 (V592I), PIK3CA (E545K), PTPN11 (S502L) |
HROG13 | ABL1 (A288S), ATM (F858L), ERBB2 (G748C), GNA11 (N336K), PTEN (S207C), VHL (E94*) |
HROG22 | PIK3CA (E545K), PTPN11 (S502L) |
HROG59 | ERBB2 (Del fs*), GNAQ (2x Del fs*), KDR (Q472H), PTEN (Q17L, M198I, L265I) |