Table 3 Analysis of MGMT promoter methylation and EGFR amplification of GBM tumors and corresponding PDX over several in vivo passages

HROG05

Tumor

M (34,5)

82×

–

PDX P2

U (0)

12×

60

HROG06

Tumor

U (0)

82×

–

PDX P0

U (0)

75×

54

PDX P1

U (0)

69×

24

PDX P2

U (0)

103×

40

PDX P3

U (0)

123×

27

PDX P4

U (0)

144×

25

PDX P5

U (0)

147×

19

HROG07

Tumor

U (0)

12×

–

PDX P2

U (0)

152×

82

PDX P4

U (0)

96×

98

HROG12

Tumor

U (1,4)

37×

–

PDX P0

U (0)

52×

123

HROG13

Tumor

U (3,9)

1×

–

PDX P1

M (4)

2×

25

PDX P2

M (5)

2×

31

PDX P3

M (15)

2×

46

HROG17

Tumor

M (14)

4×

–

PDX P2

M (11)

1×

59

HROG22

Tumor

M (22,2)

1×

–

PDX P0

M (6)

2×

158

PDX P1

M (22)

2×

54

PDX P3

M (73)

1×

46

PDX P5

M (97)

2×

26

HROG33

Tumor

U (0)

31×

–

PDX P1

U (0)

67×

90

HROG59

Tumor

U (0)

16×

–

PDX P2

U (0)

85×

68

PDX P3

U (0)

92×

31

PDX P4

U (0)

47×

31

PDX P5

U (0)

36×

54