Neuroregenerative potential of intravenous G-CSF and autologous peripheral blood stem cells in children with cerebral palsy: a randomized, double-blind, cross-over study

Rah, Wee-Jin; Lee, Young-Ho; Moon, Jin-Hwa; Jun, Hyun-Ju; Kang, Hye-Ryeong; Koh, Hani; Eom, Hye Jung; Lee, Ji Young; Lee, Young Jun; Kim, Ji Young; Choi, Yun-Young; Park, Kyeongil; Kim, Mi Jung; Kim, Seung-Hyun

doi:10.1186/s12967-017-1120-0

Table 6 Changes in FA and ADC values

From: Neuroregenerative potential of intravenous G-CSF and autologous peripheral blood stem cells in children with cerebral palsy: a randomized, double-blind, cross-over study

ROI	FA			ADC
ROI	T1	T7	p	T1	T7	p
a Changes in FA and ADC values between M0 and M13
CRR	0.028	0.035	0.849	0.017	−0.018	0.723
CRL	0.056	0.029	0.032	−0.016	−0.015	0.935
PLR	0.057	0.020	0.144	−0.023	−0.013	0.643
PLL	0.039	0.018	0.010	−0.057	0.039	0.010
MBR	−0.010	0.028	0.397	0.001	0.121	0.723
MBL	0.024	0.001	0.349	−0.079	0.004	0.238
PonsR	−0.010	0.011	0.071	−0.047	−0.051	0.849
PonsL	0.027	0.035	0.892	−0.049	0.016	0.041
PTRR	0.023	0.010	0.643	0.008	0.022	0.683
PTRL	0.016	−0.013	0.367	−0.003	−0.009	0.935
FR	0.023	0.006	0.807	−0.003	0.008	0.978
FL	−0.003	0.000	0.605	−0.023	0.028	0.238
TR	0.046	0.004	0.367	−0.154	−0.045	0.683
TL	0.043	0.030	0.683	−0.002	0.003	0.849
OR	0.024	0.023	0.935	0.033	0.009	0.531
OL	0.023	0.039	0.461	0.025	−0.035	0.605
Genu	0.055	0.027	0.238	−0.35	−0.001	0.026
Spl	0.019	0.044	0.285	0.004	−0.112	0.091
b Changes in FA and ADC values between M0 and M7
CRR	−0.011	0.041	0.070	−0.055	−0.034	0.845
CRL	0.017	0.009	0.499	−0.059	−0.033	1.000
PLR	0.003	−0.005	0.963	−0.058	−0.019	0.767
PLL	0.028	0.016	0.521	−0.084	0.009	0.020
MBR	−0.008	−0.003	0.521	−0.023	0.180	0.181
MBL	0.017	−0.007	0.481	−0.028	−0.053	0.913
PonsR	0.006	−0.007	0.964	−0.074	−0.017	0.105
PonsL	0.028	0.011	0.775	−0.063	−0.003	0.284
PTRR	−0.011	0.019	0.424	−0.033	0.019	0.839
PTRL	−0.003	−0.011	0.696	−0.045	−0.071	0.462
FR	0.013	−0.015	0.189	−0.063	−0.002	0.313
FL	−0.003	−0.035	0.298	−0.060	0.011	0.599
TR	0.006	0.007	0.845	−0.125	−0.031	0.940
TL	0.007	0.017	0.408	−0.047	−0.011	0.775
OR	−0.010	0.002	0.397	−0.044	−0.012	0.415
OL	−0.005	0.005	0.754	−0.095	−0.048	0.397
Genu	0.032	0.002	0.271	−0.107	0.025	0.070
Spl	−0.026	0.001	0.093	0.033	−0.040	0.490

M0, M7, and M13 refer to months after enrollment
FA fractional anisotropy; ADC apparent diffusion coefficient; ROI region of interest; CRR corona radiata, right; CRL corona radiata, left; PLR internal capsule, posterior limb, right; PLL internal capsule, posterior limb, left; MBR midbrain, right; MBL midbrain, left; PonsR pons, right; PonsL pons, left; PTRR posterior thalamic radiation, right; PTRL posterior thalamic radiation, left; FR frontal, right; FL frontal, left; TR temporal right; TL temporal left; OR occipital right; OL occipital left; Spl splenium

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ISSN: 1479-5876

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