1st treatment Dose (μg/kg)/infusion time (h)/infusion rate | 2nd treatment Dose (μg/kg)/infusion time (h)/infusion rate | |
---|---|---|
Group 1 | ||
Volunteer 1 | 500/2/constant | _ |
Volunteer 2 | 500/2/constant | |
Volunteer 3 | 500/2/constant | |
Group 2 | ||
Volunteer 1 | 1000/2/constant | 2500/2/constant H |
Volunteer 2 | 1000/2/constant | 2500/2/constant H |
Volunteer 3 | 1000/2/constant | – |
Volunteer 4 | 1000/2/constant | 2500/2/constant H |
Group 3 | ||
Volunteer 1 | 1000/1/constant h | 1000/2/const. rate |
Volunteer 2 | 1000/1/constant | 1000/2/const. rate |
Volunteer-3 | 1000/1/constant | 1000/2/const. rate |
Group 4 | ||
Volunteer 1 | 1500/2/constant | 2500/2/const. rate H |
Volunteer 2 | 1500/2/constant h | 2500/2/const. rate H |
Volunteer 3 | 1500/2/constant | – |
Volunteer 4 | 1500/2/constant | 2500/2/const. rate H |
Group 5 | ||
Volunteer 1 | 2000/2/constant h | – |
Volunteer 2 | 2000/2/constant | |
Volunteer 3 | 2000/2/constant h | |
Volunteer 4 | 2000/2/constant h | |
Volunteer 5 | 2000/2/constant h | |
Volunteer 6 | 2000/2/constant h | |
Group 6 | ||
Volunteer 1 | 2000/2/ramped | – |
Volunteer 2 | 2000/2/ramped h | |
Volunteer 3 | 2000/2/ramped | |
Group 7 | ||
Volunteer 1 | 2500/2/constant H | – |
Volunteer 2 | 2500/2/constantH | 1500/2/const. rate |
Volunteer 3 | 2500/2/constantH | 1500/2/const. rate |
Volunteer 4 | 2500/2/constantH | 1500/2/const. rate |