Fig. 4

Conditioned media from 3 well characterized OPSCC cells lines (JHU-011, -012, and -019) caused significant migration and invasion of MSCs. Following 24-h incubation with conditioned media from JHU-011, -012, and -019, a >60% increase in MSC migration was observed when compared to OKT controls (a). MSCs were also observed to have a significant increased capacity for invasion >50% compared to that caused by the conditioned media from OKT controls (b). All data are expressed as a percentage increase in MSC migration and invasion normalized to OKT controls. Each experiment was performed in triplicate for n ≥ 3 (p < 0.0001)