Table 2 IPA analysis
From: Targeted myocardial gene expression in failing hearts by RNA sequencing
Name | p value |
|---|---|
Top canonical pathways | |
 Calcium signaling | 9.78E−06 |
 Nitric oxide signaling in the cardiovascular system | 2.07E−05 |
 Protein kinase A signaling | 3.37E−05 |
 Tight junction signaling | 1.53E−04 |
 Hepatic fibrosis/hepatic stellate cell activation | 2.17E−04 |
Top upstream regulators | |
 IKBKG | 3.25E−08 |
 Phenylephrine | 3.50E−08 |
 Fucoidin | 9.83E−08 |
 GATA4 | 1.63E−07 |
 SLC16A3 | 2.89E−07 |
Molecular and cellular functions | |
 Cell morphology | 1.49E−03 to 1.70E−08 |
 Cellular movement | 1.40E−03 to 3.96E−08 |
 Gene expression | 1.09E−03 to 3.96E−08 |
 Cell death and survival | 1.57E−03 to 1.29E−07 |
 Cell-to-cell signaling and interaction | 1.49E−03 to 2.21E−07 |
Top tox lists | |
 Cardiac hypertrophy | 2.16E−08 |
 Cardiac necrosis/cell death | 4.44E−06 |
 Increases heart failure | 6.87E−06 |
 Cardiac fibrosis | 1.45E−05 |
 Hepatic fibrosis | 2.16E−05 |