Fig. 2

Deleterious genomic alterations, genes and tumor sites in Wild-Type GIST. Matrix demonstrating genes recurrently mutated in WT GIST patients, with each column representing an individual patient. VUS missense mutations are displayed only if they are predicted to affect gene function by 2 or more algorithms (see “Methods” section). Genes were prioritized on the basis of predicted damaging effect. The table header indicates GIST tissue of origin (blue), positive node status (red), positive metastic status (purple), qWT status (i.e. tested for SDHx—black) missing data (grey). The number of mutated patients for each gene (red scale in row header) is indicated