Fig. 5
From: Small cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2
ACh rescues the inhibitory effect of IA-2 siRNA and miR-342 mimic on SCLC cell growth. a Treatment of SCLC cells with IA-2 siRNA inhibits cell growth. In contrast, treatment of NCI-H82 cells with ACh (1 mM), rescues cell growth. The increase of proliferation in the IA-2 siRNA and ACh treated cells is significantly higher than that incubated with ACh. b Similarly, the inhibitory effect of miR-342 on NCI-H82 cell growth is reduced by ACh treatment (1 mM). Similarly, the addition of ACh to cells treated with the miR-342 inhibitor produced an increase in cell proliferation with the greatest magnitude compared to the other treatment conditions. n = 4; *P < 0.05, **P < 0.01