Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla

Table 2 Metabolite ratios with respect to Cr in patients and normal controls from the L-COSY data

Metabolites (Cr)	Chemical shift		Patient 1	Patient 2	Patient 4	Patient 5	Patient 6	Patient 9	Controls (N = 6)
Metabolites (Cr)	F₂ (ppm)	F₁ (ppm)	N/A	N/A	Grade I	Grade I/II	Grade II	Grade III	N/A
NAA-d	2.0	2.0	1.80	1.29	1.49	1.06	1.29	1.21	1.37
Cr-d	3.0	3.0	1.00	1.00	1.00	1.00	1.00	1.00	1.00
Cho-d	3.2	3.2	0.72	0.99	0.86	1.05	0.81	1.81	0.64
mI-d	3.5	3.5	0.36	0.38	0.38	0.68	0.45	0.82	0.28
Lipid-d	0.9	1.3	0.78	1.67	1.09	0.91	0.59	1.25	ND
Lac	4.1	1.3	0.05	0.09	0.14	0.06	0.04	0.10	0.01
Lys	3.0	1.7	0.14	0.12	0.16	0.11	0.12	0.11	0.10
GABA	3.0	1.9	0.10	0.08	0.15	0.11	0.08	0.08	0.07
Glu	2.4	2.0	0.21	0.23	0.21	0.20	0.24	0.19	0.23
Gln	2.5	2.1	0.19	0.39	0.19	0.19	0.21	0.26	0.20
Glx	3.7	2.1	0.09	0.15	0.09	0.11	0.11	0.14	0.17
NAA	4.4	2.5	0.05	0.03	0.04	0.02	0.04	0.03	0.05
Asp	3.9	2.8	0.03	0.04	0.05	0.07	0.05	0.07	0.05
Tau	3.4	3.2	0.14	0.12	0.16	0.12	0.08	0.19	0.09
mI	3.6	3.3	0.23	0.24	0.31	0.30	0.30	0.53	0.24
GPE/PE	3.9	3.2	0.04	0.06	0.04	0.06	0.13	0.11	0.04
2HG	4.0	1.7	ND	ND	ND	ND	0.08	0.10	ND
mI + Cho	4.1	3.3	0.04	0.06	0.04	0.05	0.07	0.08	0.06
PC	4.2	3.6	0.04	0.06	0.06	0.07	0.08	0.12	0.07
GPC	4.3	3.7	0.02	0.05	0.05	0.07	0.07	0.13	0.04
GSH	4.5	2.9	0.03	0.04	0.04	0.07	0.04	0.05	0.03

The first five rows represent data from resonances that appear as diagonal peaks (indicated by -d)
ND not detected

ISSN: 1479-5876