Fig. 5
The effects of LIVP-GFP virus on tumour growth, metastasis development and lifespan of tumour-bearing mice. a Scheme of the experiments. b, d Inhibition of melanoma B-16 (b) and lymphosarcoma RLS-40 (d) tumour growth after treatment with LIVP-GFP. Mice with tumours implanted subcutaneously for melanoma B-16 or intramuscularly for RLS-40 received two injections of either LIVP-GFP or PBS intratumourally. Tumour volume was monitored every other day, and the mean ± SD are shown; asterisk denotes statistically significant difference with P < 0.05. c Lifespan of mice with melanoma-B-16 treated with LIVP-GFP (open squares) or PBS (grey rhombus). Mouse survival was monitored for 60 days after tumour implantation. e The effect of LIVP-GFP (white bar) on metastasis development in mice with RLS-40 tumour (black bar mice received PBS)