|
WOMAC
|
Time
|
Control
|
BM-MSCs
|
|---|
|
Low-dose
|
High-dose
|
|---|
|
Pain
|
Baseline
|
5.5 (5, 6)
|
7.5 (5, 9)
|
4.5 (4, 5)
|
|
3 months
|
3 (1, 3)*
|
3.5 (3, 7)
|
3 (2, 5)
|
|
6 months
|
2.5 (1, 5)*
|
3.5 (3, 7)
|
3.5 (2, 5)
|
|
12 months
|
2 (1, 6)
|
3.5 (3, 5)
|
2.5 (2, 4)*
|
|
Stiffness
|
Baseline
|
2 (1, 3)
|
4 (2, 5)
|
2.5 (2, 4)
|
|
3 months
|
2 (1, 2)
|
2 (0, 4)
|
2 (1, 2)
|
|
6 months
|
0.5 (0, 2)
|
1.5 (1, 3)*
|
2 (1, 3)
|
|
12 months
|
2 (1, 2)
|
2 (1, 2)*
|
2 (1, 2)*
|
|
Function
|
Baseline
|
21 (13, 24)
|
26.5 (23, 32)
|
19 (12, 25)
|
|
3 months
|
9 (7, 11)*
|
17.5 (8, 26)
|
10 (7, 18)
|
|
6 months
|
7.5 (2, 13)*
|
18 (10, 23)
|
14.5 (8, 17)
|
|
12 months
|
9.5 (5, 23)
|
17 (10, 20)
|
11 (9, 14)*
|
|
Overall
|
Baseline
|
29 (19, 38)
|
37 (32, 42)
|
28 (16, 34)
|
|
3 months
|
12 (11, 14)*
|
25.5 (11, 37)
|
13 (11, 26)*
|
|
6 months
|
10 (4, 20)*
|
24 (13, 31)
|
20 (13, 23)
|
|
12 months
|
13.5 (8, 33)
|
21.5 (15, 26)
|
16.5 (12, 19)**
|
- The values of each one of the three WOMAC subscales as well as the overall WOMAC score at baseline and 3, 6 and 12 months afterwards are presented. Data are the median (IQR) of each group. Function means physical function. *p < 0.05, **p < 0.01 with respect to the baseline value of the same group
