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Table 5 Additive value of plasma MBL for the prediction of cardiovascular events in hemodialysis patients

From: Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients

 

Harrell’s C (95 % CI)

Change (95 % CI)a

IDI (%)

P

Without MBL

With MBL

Model 1

0.56 (0.46–0.66)

0.64 (0.53–0.76)

0.085 (0.072–0.098)

5.93

0.01

Model 2

0.64 (0.55–0.73)

0.67 (0.57–0.77)

0.033 (0.028–0.038)

5.35

0.01

Model 3

0.71 (0.63–0.80)

0.74 (0.65–0.83)

0.027 (0.026–0.028)

6.05

0.01

Model 4

0.73 (0.64–0.82)

0.76 (0.68–0.85)

0.033 (0.033–0.033)

6.92

0.01

  1. Data are presented as Harrell’s concordance statistic (Harrell’s C) with 95 % confidence interval (CI) and integrated discrimination improvement (IDI) with P-value (P)
  2. Model 1: age and gender
  3. Model 2: age, gender, ultrafiltration volume and dialysis vintage
  4. Model 3: age, gender, ultrafiltration volume and dialysis vintage, history of CVD, DM and post-HD systolic blood pressure
  5. Model 4: age, gender, ultrafiltration volume and dialysis vintage, history of CVD, DM and post-HD systolic blood pressure and hsCRP
  6. MBL mannose-binding lectin; CVD cardiovascular diseases; DM Diabetes Mellitus; HD hemodialysis; hsCRP high sensitive C-reactive protein
  7. aChange in C-statistics compared to model without post-hemodialysis MBL levels