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Table 5 Additive value of plasma MBL for the prediction of cardiovascular events in hemodialysis patients

From: Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients

  Harrell’s C (95 % CI) Change (95 % CI)a IDI (%) P
Without MBL With MBL
Model 1 0.56 (0.46–0.66) 0.64 (0.53–0.76) 0.085 (0.072–0.098) 5.93 0.01
Model 2 0.64 (0.55–0.73) 0.67 (0.57–0.77) 0.033 (0.028–0.038) 5.35 0.01
Model 3 0.71 (0.63–0.80) 0.74 (0.65–0.83) 0.027 (0.026–0.028) 6.05 0.01
Model 4 0.73 (0.64–0.82) 0.76 (0.68–0.85) 0.033 (0.033–0.033) 6.92 0.01
  1. Data are presented as Harrell’s concordance statistic (Harrell’s C) with 95 % confidence interval (CI) and integrated discrimination improvement (IDI) with P-value (P)
  2. Model 1: age and gender
  3. Model 2: age, gender, ultrafiltration volume and dialysis vintage
  4. Model 3: age, gender, ultrafiltration volume and dialysis vintage, history of CVD, DM and post-HD systolic blood pressure
  5. Model 4: age, gender, ultrafiltration volume and dialysis vintage, history of CVD, DM and post-HD systolic blood pressure and hsCRP
  6. MBL mannose-binding lectin; CVD cardiovascular diseases; DM Diabetes Mellitus; HD hemodialysis; hsCRP high sensitive C-reactive protein
  7. aChange in C-statistics compared to model without post-hemodialysis MBL levels