Fig. 1

Representative in vivo images of WT and CF mice transiently transgenized with bIL-8-Luc and intratracheally challenged with hTNF-alpha (1 µg/mouse) and monitoring of bIL-8 activation by BLI. a, c: WT and CF mice treated with saline solution (control). b, d: WT and CF mice after intratracheal instillation with hTNF-alpha and monitoring of IL-8 activation at 4, 24 and 48 h by BLI. e: Time-course of IL-8-Luc activation in WT and CF mice. Results are reported as folds of increase (FOI) over baseline as mean ± SEM, n = 9 each group. Statistical differences were tested by one-way ANOVA followed by Dunnett’s t post hoc test for group comparisons. *p < 0.05 and **p < 0.01