Fig. 7
From: Immune response and innervation signatures in aseptic hip implant loosening
TGF-β1 expression in synovial membrane-like interface tissues and OA synovial tissues. a TGF-β1+ endothelial cells in aseptic interface tissue with metallosis. b TGF-β1+ macrophages in synovial membrane-like interface tissue. c TGF-β1+ fibroblast in aseptic interface membrane. d Number of OA and AL patients classified with score from 0 to 3 regarding the presence of TGF-β1 in tissue. e OA synovial membrane with positive labelling at sublining layer and endothelium (black arrows). f Lymphocyte aggregate in OA synovial tissue with positive cells for TGF-β1. g Aseptic interface membrane presenting heterogenous TGF-β1 labelling. h Multinucleated giant cell (GC) phagocytosing a polymeric particle (PP) with ZrO2 particles inside (black clusters) with TGF-β1+ endothelial cells in the vicinity. Scale bars correspond to 500 μm (g) and 50 μm (a, b, c, e, f, h). Data was collected for 11/15 OA patients and for 19/20 AL patients. Chi square test was used to compare OA and AL groups