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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: HBx-induced MiR-1269b in NF-κB dependent manner upregulates cell division cycle 40 homolog (CDC40) to promote proliferation and migration in hepatoma cells

Fig. 5

CDC40 promotes cell proliferation and migration, which is regulated by miR-1269b. a Colony formation assays were performed to test the influence of CDC40 on proliferation in HepG2 and SMMC-7721 cells. b Cell cycle progression in the transfected cells was analyzed using flow cytometry. The chart shows the populations of cells in the different phases of the cell cycle. c Transwell migration assays were performed to detect the effect of CDC40 on the migration of HepG2 and SMMC-7721 cells. d The influence of CDC40 on the protein levels of the EMT-associated molecules E-cadherin and vimentin was determined using western blot analysis. Cells were transfected 48 h before proteins were harvested. Error bars indicate the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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