Table 1 Information of similar known drugs and the corresponding putative targets of GSZD
Herbs | Known drug | Putative target of GSZD | Type of target | Indication |
|---|---|---|---|---|
Raidix Saposhnikoviae | Propofol | FAAH | Successful target | Anesthetic |
Radix Glycytthizae | Fluocinonide | PLA2G1B | Successful target | Inflammatory diseases |
Herba Ephedrae/Radix Glycytthizae/Paeonia lactiflora/Rhizoma Zingiberis Recens | Amcinonide/betamethasone/fluorometholone/fluticasone/medrysone/methylprednisolone/prednisone | NR3C1 | Successful target | Inflammatory diseases/Rheumatoid arthritis |
Herba Ephedrae/Radix Glycytthizae/Paeonia lactiflora/Rhizoma Zingiberis Recens | Alclometasone/fluocinolone acetonide/fluocinonide/flurandrenolide/paramethasone/prednisolone/triamcinolone | SERPINA6 | Successful target | Autoimmune diseases/Inflammatory diseases/Rheumatoid arthritis |
Herba Ephedrae/Radix Aconiti Lateralis Preparata/Radix Glycytthizae/Raidix Saposhnikoviae/Ramulus Cinnamomi/Rhizoma Atractylodis Macrocephalae/Rhizoma Zingiberis Recens/ | Glycopyrrolate | CHRM1 | Successful target | Anesthetic |
Herba Ephedrae/Radix Aconiti Lateralis Preparata/Radix Glycytthizae/Raidix Saposhnikoviae/Ramulus Cinnamomi/Rhizoma Atractylodis Macrocephalae/Rhizoma Zingiberis Recens | Butalbital/ethanol/methohexital/talbutal/thiamylal | GABRA1 | Successful target | Anesthetic/Pain/Sedation |
Rhizoma Zingiberis Recens | Frovatriptan/sumatriptan/rizatriptan/almogran | HTR1D | Successful target | Pain |
Rhizoma Zingiberis Recens | Almotriptan/eletriptan/frovatriptan/naratriptan/zolmitriptan | HTR1B | Successful target | Pain |
Radix Glycytthizae | Hydrocortisone | NOS2 | Successful target | Inflammatory diseases |
Raidix Saposhnikoviae/Rhizoma Zingiberis Recens | Ibuprofen/etodolac/carprofen | PTGS2 | Successful target | Pain |
Herba Ephedrae/Radix Aconiti Lateralis Preparata/Radix Glycytthizae/Raidix Saposhnikoviae/Ramulus Cinnamomi/Rhizoma Atractylodis Macrocephalae/Rhizoma Zingiberis Recens | Naloxone | OPRM1 | Successful target | Anesthetic |
Radix Aconiti Lateralis Preparata/Radix Glycytthizae | Codeine/Hydromorphone | OPRD1 | Successful target | Pain |
Rhizoma Zingiberis Recens | Naloxone | FNTA | Successful target | Anesthetic |
Radix Glycytthizae | N-acetyl-d-glucosamine | NAGLU | Successful target | Autoimmune diseases |
Rhizoma Zingiberis Recens | Metocurine/mivacurium/pipecuronium | CHRNA2 | Successful target | Anesthetic/Pain |