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Table 1 Information of similar known drugs and the corresponding putative targets of GSZD

From: Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance

Herbs Known drug Putative target of GSZD Type of target Indication
Raidix Saposhnikoviae Propofol FAAH Successful target Anesthetic
Radix Glycytthizae Fluocinonide PLA2G1B Successful target Inflammatory diseases
Herba Ephedrae/Radix Glycytthizae/Paeonia lactiflora/Rhizoma Zingiberis Recens Amcinonide/betamethasone/fluorometholone/fluticasone/medrysone/methylprednisolone/prednisone NR3C1 Successful target Inflammatory diseases/Rheumatoid arthritis
Herba Ephedrae/Radix Glycytthizae/Paeonia lactiflora/Rhizoma Zingiberis Recens Alclometasone/fluocinolone acetonide/fluocinonide/flurandrenolide/paramethasone/prednisolone/triamcinolone SERPINA6 Successful target Autoimmune diseases/Inflammatory diseases/Rheumatoid arthritis
Herba Ephedrae/Radix Aconiti Lateralis Preparata/Radix Glycytthizae/Raidix Saposhnikoviae/Ramulus Cinnamomi/Rhizoma Atractylodis Macrocephalae/Rhizoma Zingiberis Recens/ Glycopyrrolate CHRM1 Successful target Anesthetic
Herba Ephedrae/Radix Aconiti Lateralis Preparata/Radix Glycytthizae/Raidix Saposhnikoviae/Ramulus Cinnamomi/Rhizoma Atractylodis Macrocephalae/Rhizoma Zingiberis Recens Butalbital/ethanol/methohexital/talbutal/thiamylal GABRA1 Successful target Anesthetic/Pain/Sedation
Rhizoma Zingiberis Recens Frovatriptan/sumatriptan/rizatriptan/almogran HTR1D Successful target Pain
Rhizoma Zingiberis Recens Almotriptan/eletriptan/frovatriptan/naratriptan/zolmitriptan HTR1B Successful target Pain
Radix Glycytthizae Hydrocortisone NOS2 Successful target Inflammatory diseases
Raidix Saposhnikoviae/Rhizoma Zingiberis Recens Ibuprofen/etodolac/carprofen PTGS2 Successful target Pain
Herba Ephedrae/Radix Aconiti Lateralis Preparata/Radix Glycytthizae/Raidix Saposhnikoviae/Ramulus Cinnamomi/Rhizoma Atractylodis Macrocephalae/Rhizoma Zingiberis Recens Naloxone OPRM1 Successful target Anesthetic
Radix Aconiti Lateralis Preparata/Radix Glycytthizae Codeine/Hydromorphone OPRD1 Successful target Pain
Rhizoma Zingiberis Recens Naloxone FNTA Successful target Anesthetic
Radix Glycytthizae N-acetyl-d-glucosamine NAGLU Successful target Autoimmune diseases
Rhizoma Zingiberis Recens Metocurine/mivacurium/pipecuronium CHRNA2 Successful target Anesthetic/Pain