Skip to main content

Table 1 DOC-Score (diagnosing oral cancer with the help of CLE)

From: Development and validation of a classification and scoring system for the diagnosis of oral squamous cell carcinomas through confocal laser endomicroscopy

Evaluation criterion Manifestation Score
1. Tissue architecture
 a) Homogeneity Completely organized 0
Organized + unorganized regions 1
Completely unorganized 2
 b) Intercellular gaps Regular 0
Mutated 1
No longer/non-existent 2
2. Cell morphology Consistent/regular 0
Inconsistent/dysplastic (different sizes/shapes/grey levels) 1
Completely irregular
 Dark, small cells
 Blurry, cloudy image
 Black spot (cell cluster)
3. Fluorescence leakage Regular 0
Amplified (bright background) 1
4. Vessels Regular 0
 Shape (micro vessels, coiled, elongated etc.)
 Caliber (increased)
 Quantity (cumulated)
x ≥ 5 points = squamous cell carcinoma (SCC) Max. total: 8 points
  1. CLE classification and scoring system of oral squamous cell carcinomas