Table 1 DOC-Score (diagnosing oral cancer with the help of CLE)
Evaluation criterion | Manifestation | Score |
|---|---|---|
1. Tissue architecture | ||
 a) Homogeneity | Completely organized | 0 |
Organized + unorganized regions | 1 | |
Completely unorganized | 2 | |
 b) Intercellular gaps | Regular | 0 |
Mutated | 1 | |
No longer/non-existent | 2 | |
2. Cell morphology | Consistent/regular | 0 |
Inconsistent/dysplastic (different sizes/shapes/grey levels) | 1 | |
Completely irregular  Dark, small cells  Blurry, cloudy image  Black spot (cell cluster) | 2 | |
3. Fluorescence leakage | Regular | 0 |
Amplified (bright background) | 1 | |
4. Vessels | Regular | 0 |
Irregular  Shape (micro vessels, coiled, elongated etc.)  Caliber (increased)  Quantity (cumulated) | 1 | |
x ≥ 5 points = squamous cell carcinoma (SCC) | Max. total: 8 points | |