Skip to main content

Table 5 Univariate analysis of the impact of serine/glycine-related protein expression in papillary thyroid carcinoma on disease-free and overall survival by the log-rank test

From: Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype

Parameter Number of patientsa/recurrence/death Disease-free survival Overall survival
Mean survival (95 % CI) months p value Mean survival (95 % CI) months p value
PHGDH in tumor 0.790   0.806
 Negative 126/6/6 105 (101–108)   106 (103–109)  
 Positive 218/12/12 106 (104–109)   107 (105–110)  
PSAT1 in tumor 0.159   0.231
 Negative 280/17/13 106 (103–109)   108 (106–110)  
 Positive 64/1/5 108 (105–111)   103 (97–108)  
PSPH in tumor 0.606   0.221
 Negative 300/15/14 107 (105–109)   108 (106–110)  
 Positive 44/3/4 103 (96–110)   103 (96–109)  
SHMT1 in tumor 0.498   0.248
 Negative 236/11/10 107 (105–110)   108 (106–110)  
 Positive 108/7/8 104 (100–109)   105 (101–109)  
SHMT1 in stroma 0.655   0.684
 Negative 212/12/10 106 (103–109)   108 (106–110)  
 Positive 132/6/8 107 (104–111)   107 (103–110)  
GLDC in tumor 0.516   0.059
 Negative 285/14/12 107 (105–109)   108 (106–110)  
 Positive 59/4/6 104 (97–110)   103 (97–109)  
  1. CI confidence interval; PHGDH phosphoglycerate dehydrogenase; PSAT phosphoserine aminotransferase; PSPH phosphoserine phosphatase; SHMT serine hydromethyl transferase; GLDC glycine decarboxylase
  2. aCases of anaplastic carcinoma were excluded