Table 2 Expression of glutamine metabolism-related proteins according to the histologic subtype of PTC
Parameters | Total n = 344 (%) | Histologic subtype | p value | BRAF V600E mutation status | p value | ||
|---|---|---|---|---|---|---|---|
Conventional type n = 304 (%) | Follicular variant n = 40 (%) | No mutation n = 106 (%) | Mutation n = 238 (%) | ||||
PHGDH in tumor | 0.564 | Â | <0.001 | ||||
 Negative | 126 (36.6) | 113 (37.2) | 13 (32.5) |  | 63 (59.4) | 63 (26.5) |  |
 Positive | 218 (63.4) | 191 (62.8) | 27 (67.5) |  | 43 (40.6) | 175 (73.5) |  |
PSAT1 in tumor | 0.501 | Â | 0.001 | ||||
 Negative | 280 (81.4) | 249 (81.9) | 31 (77.5) |  | 97 (91.5) | 183 (76.9) |  |
 Positive | 64 (18.6) | 55 (18.1) | 9 (22.5) |  | 9 (8.5) | 55 (23.1) |  |
PSPH in tumor | 0.041 | Â | <0.001 | ||||
 Negative | 300 (87.2) | 261 (85.9) | 39 (97.5) |  | 104 (98.1) | 196 (82.4) |  |
 Positive | 44 (12.8) | 43 (14.1) | 1 (2.5) |  | 2 (1.9) | 42 (17.6) |  |
SHMT1 in tumor | 0.018 | Â | 0.001 | ||||
 Negative | 236 (68.6) | 202 (66.4) | 34 (85.0) |  | 86 (81.1) | 150 (63.0) |  |
 Positive | 108 (31.4) | 102 (33.6) | 6 (15.0) |  | 20 (18.9) | 88 (37.0) |  |
SHMT1 in stroma | <0.001 | Â | <0.001 | ||||
 Negative | 212 (61.6) | 176 (57.9) | 36 (90.0) |  | 83 (78.3) | 129 (54.2) |  |
 Positive | 132 (38.4) | 128 (42.1) | 4 (10.0) |  | 23 (21.7) | 109 (45.8) |  |
GLDC in tumor | 0.116 | Â | <0.001 | ||||
 Negative | 285 (82.8) | 248 (81.6) | 37 (92.5) |  | 99 (93.4) | 186 (78.2) |  |
 Positive | 59 (17.2) | 56 (18.4) | 3 (7.5) |  | 7 (6.6) | 52 (21.8) |  |