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Table 2 Expression of glutamine metabolism-related proteins according to the histologic subtype of PTC

From: Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype

Parameters Total n = 344 (%) Histologic subtype p value BRAF V600E mutation status p value
Conventional type n = 304 (%) Follicular variant n = 40 (%) No mutation n = 106 (%) Mutation n = 238 (%)
PHGDH in tumor 0.564   <0.001
 Negative 126 (36.6) 113 (37.2) 13 (32.5)   63 (59.4) 63 (26.5)  
 Positive 218 (63.4) 191 (62.8) 27 (67.5)   43 (40.6) 175 (73.5)  
PSAT1 in tumor 0.501   0.001
 Negative 280 (81.4) 249 (81.9) 31 (77.5)   97 (91.5) 183 (76.9)  
 Positive 64 (18.6) 55 (18.1) 9 (22.5)   9 (8.5) 55 (23.1)  
PSPH in tumor 0.041   <0.001
 Negative 300 (87.2) 261 (85.9) 39 (97.5)   104 (98.1) 196 (82.4)  
 Positive 44 (12.8) 43 (14.1) 1 (2.5)   2 (1.9) 42 (17.6)  
SHMT1 in tumor 0.018   0.001
 Negative 236 (68.6) 202 (66.4) 34 (85.0)   86 (81.1) 150 (63.0)  
 Positive 108 (31.4) 102 (33.6) 6 (15.0)   20 (18.9) 88 (37.0)  
SHMT1 in stroma <0.001   <0.001
 Negative 212 (61.6) 176 (57.9) 36 (90.0)   83 (78.3) 129 (54.2)  
 Positive 132 (38.4) 128 (42.1) 4 (10.0)   23 (21.7) 109 (45.8)  
GLDC in tumor 0.116   <0.001
 Negative 285 (82.8) 248 (81.6) 37 (92.5)   99 (93.4) 186 (78.2)  
 Positive 59 (17.2) 56 (18.4) 3 (7.5)   7 (6.6) 52 (21.8)  
  1. PTC papillary thyroid carcinoma; PHGDH phosphoglycerate dehydrogenase; PSAT phosphoserine aminotransferase; PSPH phosphoserine phosphatase; SHMT serine hydromethyl transferase; GLDC glycine decarboxylase
  2. Italic values represent p < 0.05