Fig. 4

Effect of renal denervation (RDN) on the renin-angiotensin-aldosterone system (RAAS) and on expression of inflammatory cytokines in isolated mononuclear cells. a Quantification of plasma aldosterone and angiotensin II. b Evaluation of renal tissue level of renin and angiotensin II c quantification of mRNA expression levels in mononuclear cells (MNCs) of IL1β, IL6 and TNFα in SD-sham (n = 5), SD-RDN (n = 6), ApoE^−\−-sham (n = 5), ApoE^−\−-RDN (n = 6). Values are mean ± SEM. Plasma aldosterone: SD-sham vs. SD-RDN, p = 0.60 (n.s.); Plasma angiotensin II: SD-sham vs. ApoE^−/−-sham, p = 0.15 (n.s.); ApoE-sham vs. ApoE^−/−-RDN, p = 0.07 (n.s.); SD-sham vs. SD-RDN, p = 0.08 (n.s.). Tissue renin SD-sham vs. ApoE^−/−-sham, p = 0.93 (n.s.). Tissue angiotensin II SD-sham vs. ApoE^−/−-sham, p = 0.57 (n.s.). TNFα SD-sham vs. SD-RDN, p = 0.78 (n.s.); IL6 SD-sham vs. SD-RDN, p = 0.91 (n.s.); IL1β SD-sham vs. SD-RDN, p = 0.86 (n.s.); ApoE^−\−-sham vs. ApoE^−\−-RDN, p = 0.87 (n.s.); SD-sham vs. ApoE^−\−-sham, p = 0.14 (n.s.); *p < 0.05, **p < 0.01; ***p < 0.001