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Table 1 Gene ontology analysis of hypermethylated GpG sites from birth to 5 years of age (with RR >2 and Q Value <0.001)

From: Longitudinal study of DNA methylation during the first 5 years of life

Onthology

Term

RR

Q_value

Biological_process

Digestive tract morphogenesis

6.3551

2.25E−05

Biological_process

Homophilic cell adhesion

4.6179

7.02E−09

Biological_process

Digestive tract development

3.6972

0.0001

Biological_process

Locomotory behavior

3.6791

1.77E−07

Biological_process

Cell–cell adhesion

3.6197

1.63E−07

Biological_process

Digestive system development

3.3312

0.00035

Biological_process

Hindbrain development

3.1444

0.00072

Biological_process

Cell fate commitment

2.7058

0.00011

Biological_process

Behavior

2.4935

2.83E−08

Biological_process

Embryonic organ morphogenesis

2.4633

0.00027

Biological_process

Single-organism behavior

2.3998

3.88E−05

Biological_process

Cell adhesion

2.3899

4.55E−13

Biological_process

Regionalization

2.381

0.00015

Biological_process

Biological adhesion

2.3795

4.55E−13

Biological_process

Brain development

2.2605

4.09E−08

Biological_process

Pattern specification process

2.2365

5.37E−05

Biological_process

Central nervous system development

2.2029

5.18E−10

Biological_process

Muscle structure development

2.1471

0.00017

Biological_process

Embryonic morphogenesis

2.1396

1.59E−05

Biological_process

Embryonic organ development

2.0979

0.00047

Biological_process

Skeletal system development

2.0909

0.00035

Molecular_function

Sequence-specific DNA binding

2.0117

2.71E−06

Cellular_component

Dendrite

2.3717

1.38E−05

Cellular_component

Axon

2.2741

0.00099

Cellular_component

Somatodendritic compartment

2.1637

4.07E−06

  1. RR relative risk is a measure of effect size describing the change of proportions between our selected set of genes and a given term
  2. Q value Q value is the result from the adjustment of P values in order to control the false discovery rate (FDR) using the Benjamini-Hochberg method