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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Fig. 5

Synovial macrophages in ApoE−/− mice have an MHCII+ phenotype and exhibit characteristics of foamy macrophages. Flow cytometric analysis of synovium from 18-week-old non-arthritic and arthritic C57BL/6 (control) and ApoE−/− mice (n = 4–5 mice/group). a Total number of synovial macrophages. b The ratio of MHCII+ to MHC II synovial macrophages. c Histogram of oxidized LDL scavenger receptor, CD36, is shown with concatenation of samples from one experiment of non-arthritic control (black) and ApoE−/− (red) mice. Geometric mean illustrates CD36 expression in d MHCII and e MHCII+ macrophages of individual mice. f Histogram representing uptake of lipophilic dye (BoDIPY) in a concatenation of samples from one experiment of non-arthritic control (black) and ApoE−/− (red) mice. No dye control (grey) is included. Cumulative data displayed as geometric means in g MHCII and h MHCII+ macrophages. i Histogram of side scatter (SSC) of concatenation of samples from one experiment of non-arthritic control (black) and ApoE−/− (red) mice is shown with a composite of samples illustrated as geometric mean of j MHCII and k MHCII+ macrophages. Asterisk denotes statistically significant differences: *p < 0.05, **p < 0.01

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