Fig. 5
Effect of cathepsin A inhibition on proteome alterations in LAD ligation. a Bar chart depiction of proteins that are significantly increased in placebo-treated LAD ligation (as compared to sham operation) and for which SAR1 treatment decreased this effect by a fold-change value of more than 50 % [difference of log2 ratios (MI-placebo/sham)–(MI-SAR1/sham) > 0.58]. b Same as (a) but for significantly decreased proteins in LAD ligation. Results are expressed as mean ± SEM. Differences significant at p < 0.05 are marked with an asterisk (*). c Western blot analysis of selected proteins. Shown here is a representative blot. GAPDH is used as loading control