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Table 3 Stratified multivariate analysis of DFS and OS between LG* and HG* in Chinese ESCC patients

From: Genetic variants of DNA repair genes predict the survival of patients with esophageal squamous cell cancer receiving platinum-based adjuvant chemotherapy

Variables

No. of patients (LG/HG)

DFS

OS

Progression no. (%) (LG/HG)

Multivariate analysis

P value

Death no. (%) (LG/HG)

Multivariate analysis

P value

Age

       

 <60

149/32

86 (57.7)/24 (75.0)

1.94 (1.21–3.10)

0.006

71 (47.7)/24 (75.0)

2.41 (1.49–3.90)

0.0004

 ≥60

138/25

89 (64.5)/21 (84.0)

1.40 (0.85–2.32)

0.187

81 (58.7)/20 (80.0)

1.27 (0.76–2.14)

0.360

Sex

       

 Male

246/49

153 (62.2)/41(83.7)

1.76 (1.24–2.51)

0.002

133 (54.1)/40 (81.6)

1.89 (1.32–2.71)

0.0005

 Female

41/8

22 (53.7)/4 (50)

0.62 (0.16–2.32)

0.474

19 (46.3)/4 (50.0)

074 (0.19–2.90)

0.660

Smoking

       

 Never

100/22

56 (56.0)/16 (72.7)

1.54 (0.86–1.74)

0.146

45 (45.0)/16 (72.7)

1.74 (0.96–3.17)

0.069

 Yes

187/35

119 (63.6)/29 (82.9)

1.71 (1.12–2.60)

0.012

107 (57.2)/28 (80.0)

1.77 (1.16–2.72)

0.008

Drinking

       

 No

143/28

82 (57.3)/21 (75)

1.74 (1.05–2.87)

0.032

72 (50.4)/20 (71.4)

1.87 (1.11–3.15)

0.018

 Yes

144/29

93 (64.6)/24 (82.8)

1.74 (1.08–2.80)

0.022

80 (55.6)/24 (82.8)

1.93 (1.20–3.12)

0.007

Vessel invasion

       

 No

207/36

114 (55.1)/28 (77.8)

2.38 (1.56–3.63)

<0.001

96 (46.4)/26 (72.2)

2.07 (1.33–3.22)

0.001

 Yes

80/21

61 (76.3)/17 (81.0)

1.12 (0.64–2.95)

0.699

56 (70.0)/28 (85.7)

1.61 (0.92–2.83)

0.098

Neural invasion

       

 No

214/40

129 (60.3)/32 (80.0)

1.72 (1.16–2.55)

0.007

111 (51.9)/30 (75.0)

1.71 (1.13–1.58)

0.011

 Yes

73/17

46 (63.0)/13 (76.5)

1.29 (0.64–2.59)

0.477

41 (56.2)/14 (82.4)

1.54 (0.75–3.16)

0.241

TNM stage

       

 II

96/20

43 (44.8)/15 (75.0)

2.06 (1.14–3.72)

0.006

38 (39.6)/14 (70)

2.40 (1.29–4.45)

0.006

 III

191/37

132 (69.1)/30 (81.1)

1.44 (0.95–2.17)

0.084

114 (59.7)/30 (81.1)

1.62 (1.07–2.45)

0.024

Lymphadenectomy

       

 Two fields

237/44

138 (58.2)/34 (77.3)

1.67 (1.13–2.45)

0.009

119 (50.2)/34 (77.3)

1.99 (1.34–1.94)

0.006

 Three fields

50/13

37 (74.0)/11 (84.6)

2.17 (1.00–4.74)

0.051

33 (66.0)/10 (76.9)

1.59 (0.72–3.52)

0.256

  1. * LG consisted of 0–1 risk genotypes and HG consisted of 2–3 risk genotypes
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Journal of Translational Medicine

ISSN: 1479-5876

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