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Table 3 Stratified multivariate analysis of DFS and OS between LG* and HG* in Chinese ESCC patients

From: Genetic variants of DNA repair genes predict the survival of patients with esophageal squamous cell cancer receiving platinum-based adjuvant chemotherapy

Variables No. of patients (LG/HG) DFS OS
Progression no. (%) (LG/HG) Multivariate analysis P value Death no. (%) (LG/HG) Multivariate analysis P value
Age        
 <60 149/32 86 (57.7)/24 (75.0) 1.94 (1.21–3.10) 0.006 71 (47.7)/24 (75.0) 2.41 (1.49–3.90) 0.0004
 ≥60 138/25 89 (64.5)/21 (84.0) 1.40 (0.85–2.32) 0.187 81 (58.7)/20 (80.0) 1.27 (0.76–2.14) 0.360
Sex        
 Male 246/49 153 (62.2)/41(83.7) 1.76 (1.24–2.51) 0.002 133 (54.1)/40 (81.6) 1.89 (1.32–2.71) 0.0005
 Female 41/8 22 (53.7)/4 (50) 0.62 (0.16–2.32) 0.474 19 (46.3)/4 (50.0) 074 (0.19–2.90) 0.660
Smoking        
 Never 100/22 56 (56.0)/16 (72.7) 1.54 (0.86–1.74) 0.146 45 (45.0)/16 (72.7) 1.74 (0.96–3.17) 0.069
 Yes 187/35 119 (63.6)/29 (82.9) 1.71 (1.12–2.60) 0.012 107 (57.2)/28 (80.0) 1.77 (1.16–2.72) 0.008
Drinking        
 No 143/28 82 (57.3)/21 (75) 1.74 (1.05–2.87) 0.032 72 (50.4)/20 (71.4) 1.87 (1.11–3.15) 0.018
 Yes 144/29 93 (64.6)/24 (82.8) 1.74 (1.08–2.80) 0.022 80 (55.6)/24 (82.8) 1.93 (1.20–3.12) 0.007
Vessel invasion        
 No 207/36 114 (55.1)/28 (77.8) 2.38 (1.56–3.63) <0.001 96 (46.4)/26 (72.2) 2.07 (1.33–3.22) 0.001
 Yes 80/21 61 (76.3)/17 (81.0) 1.12 (0.64–2.95) 0.699 56 (70.0)/28 (85.7) 1.61 (0.92–2.83) 0.098
Neural invasion        
 No 214/40 129 (60.3)/32 (80.0) 1.72 (1.16–2.55) 0.007 111 (51.9)/30 (75.0) 1.71 (1.13–1.58) 0.011
 Yes 73/17 46 (63.0)/13 (76.5) 1.29 (0.64–2.59) 0.477 41 (56.2)/14 (82.4) 1.54 (0.75–3.16) 0.241
TNM stage        
 II 96/20 43 (44.8)/15 (75.0) 2.06 (1.14–3.72) 0.006 38 (39.6)/14 (70) 2.40 (1.29–4.45) 0.006
 III 191/37 132 (69.1)/30 (81.1) 1.44 (0.95–2.17) 0.084 114 (59.7)/30 (81.1) 1.62 (1.07–2.45) 0.024
Lymphadenectomy        
 Two fields 237/44 138 (58.2)/34 (77.3) 1.67 (1.13–2.45) 0.009 119 (50.2)/34 (77.3) 1.99 (1.34–1.94) 0.006
 Three fields 50/13 37 (74.0)/11 (84.6) 2.17 (1.00–4.74) 0.051 33 (66.0)/10 (76.9) 1.59 (0.72–3.52) 0.256
  1. * LG consisted of 0–1 risk genotypes and HG consisted of 2–3 risk genotypes