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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters

Fig. 5

Evaluation of inflammatory response to CRAd-S-pk7 administration over time. Cell counts for total white blood cells (WBC) (a, b) neutrophils (c, d), and monocytes (e, f) were determined from the peripheral blood of both male and female hamsters in vehicle and vector-treated groups on days 6, 34, and 62 for the doses shown (n = 5 animals/group). The analyzed measurements are shown as number of cells per mm3 (×103). Standard deviations are indicated by error bars. One-way ANOVA and Kruskal–Wallis test were used for comparison of cell counts between animals from vehicle (G2) and treated (G3-5) groups; ns, P > 0.05

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