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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters

Fig. 1

Schematic of genome of CRAd-S-pk7. The fiber knob domain has seven lysine residues added to the C-terminal end to enhance the infectivity of the virus. The essential early replication gene (E1) is under the transcriptional control of the tumor-specific promoter survivin (S) to restrict viral replication to tumor cells (oncolysis)

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Journal of Translational Medicine

ISSN: 1479-5876

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