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Table 3 Regions of GMV difference between pre- and post-operative scans of the patients and controls, and pre- and post-operative longitudinal changes in the OSA group

From: Longitudinal brain structural alterations and systemic inflammation in obstructive sleep apnea before and after surgical treatment

MNI atlas coordinates Cluster size Anatomical region Brodmann area t-score
x Y z
Regional GMV decrease in OSAbaseline vs. NC   
−4 28 19 456 Left Anterior Cingulate Gyrus 24 3.41
Regional GMV increase in OSAbaseline vs. NC   
40 −7 −6 612 Right Insula 13 2.99
Regional GMV decrease in OSAfollow vs. NC   
−4 28 19 663 Left Anterior Cingulate Gyrus 24 3.65
Regional GMV decrease in OSAfollow vs. OSAbaseline   
−24 −37 4 1047 Left Hippocampus (Hipp) 30 5.23
−7 −52 28   Left Posterior Cingulate Gyrus (PCG) 31 3.63
−24 −51 17   Left Precuneus 30 3.55
−49 4 −1 1566 Left Superior Temporal Gyrus (STG) 22 4.48
−42 29 −2   Left Inferior Frontal Gyrus (IFG) 47 3.86
−27 25 −3   Left Insula 13 3.61
Regional GMV increase in OSAfollow vs. OSAbaseline   
−15 −81 −27 1254 Left Cerebellum 4.18
  1. Gray matter volume (GMV) differences between groups are described in terms of MNI coordinates, voxel extent, brain side, and corresponding anatomical regions. The t-score of the voxel with the strongest group effect in a given cluster is also listed. The statistical criteria of the VBM results were set as a cluster level FWE corrected p < 0.05 (using a Monte Carlo simulation to correct the multiple comparison problem)
  2. FWE family wised error; Lt left side; MNI Montreal Neurological Institute; Rt right side; VBM voxel-based morphometry