Skip to main content

Advertisement

Table 2 Associations of EGFR status with clinicopathological characteristics in three independent CRC patient cohorts

From: Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer

EGFR Cohort 1 p value Cohort 2 p value Cohort 3 p value
Low High Low High Low High
N (%) 419 (78.6) 114 (21.4)   202 (78.0) 57 (21.1)   259 (83.5) 51 (16.5)  
Age
 Mean, median 70.6, 71.4 69.9, 71.3 0.439 72.6, 73.5 70.7, 73.1 0.401 71.1, 73.0 71.5, 74.0 0.977
 Range 51.3–85.6 49.8–83.5   37.6–92.1 37.8–93.3   36.0–94.0 50.0–87.0  
Sex
 Female 219 (52.3) 62 (54.4) 0.688 98 (48.5) 34 (59.6) 0.138 129 (49.8) 29 (56.9) 0.358
 Male 200 (47.7) 52 (45.6)   104 (51.5) 23 (40.4)   130 (50.2) 22 (43.1)  
Location
 Colon 258 (61.9) 76 (66.7) 0.348 161 (79.7) 48 (85.7) 0.311 177 (68.3) 30 (58.8) 0.188
 Rectum 159 (38.1) 38 (33.3)   41 (20.3) 8 (14.3)   82 (31.7) 21 (41.2)  
 Missing 2         
T-stage
 T1 43 (10.9) 1 (0.9) <0.001 14 (7.1) 4 (7.1) 0.432 11 (4.2) 0 (0.0) 0.002
 T2 55 (13.9) 7 (6.2)   53 (26.8) 11 (19.6)   38 (14.7) 1 (2.0)  
 T3 249 (62.9) 75 (67.0)   107 (54.0) 33 (58.9)   169 (65.3) 37 (72.5)  
 T4 49 (12.4) 29 (25.9)   24 (14.3) 8 (14.3)   41 (15.8) 13 (25.5)  
 Missing 23 2   4 1     
N-stage
 N0 232 (61.7) 48 (43.2) 0.002 129 (64.8) 33 (61.1) 0.331 164 (63.39 18 (35.3) <0.001
 N1 87 (23.1) 34 (30.6)   50 (25.1) 12 (22.2)   53 (20.5) 9 (17.6)  
 N2 57 (15.2) 29 (26.1)   20 (10.1) 9 (16.7)   42 (16.2) 24 (47.1)  
 Missing 43 3   3 3     
M-stage
 M0 349 (84.5) 82 (72.6) 0.003 180 (89.6) 40 (72.7) 0.002 232 (89.6) 39 (76.5) 0.010
 M1 64 (15.5) 31 (27.4)   21 (10.4) 15 (27.3)   27 (10.4) 12 (23.5)  
 Missing 6 1   1 2     
Diff. grade
 High 28 (6.8) 4 (3.6) <0.001 16 (7.9) 5 (8.8) 0.402 8 (3.1) 1 (2.0) 0.006
 Intermediate 310 (75.4) 62 (55.4)   138 (68.3) 34 (59.6)   202 (78.0) 31 (60.8)  
 Low 73 (17.8) 46 (41.1)   48 (23.8) 18 (31.6)   49 (18.9) 19 (37.3)  
 Missing 8 2        
Vasc. invasion
 No 125 (53.2) 27 (34.2) 0.003 108 (54.8) 24 (44.4) 0.177 233 (90.0) 38 (74.5) 0.002
 Yes 110 (46.8) 52 (65.8)   89 (45.2) 30 (55.6)   26 (10.0) 13 (25.5)  
 Missing 184 35   5 3     
MSI status
 MSS 333 (85.4) 85 (81.0) 0.266 N/A N/A   214 (82.9) 47 (92.2) 0.098
 MSI 57 (14.6) 20 (19.0)   N/A N/A   44 (17.1) 4 (7.8)  
 Missing 29 9      1   
KRAS status
 Wild-type 253 (63.9) 66 (61.1) 0.596 N/A N/A   108 (63.5) 24 (70.6) 0.433
 Mutated 119 (36.1) 42 (38.9)   N/A N/A   62 (36.5) 10 (29.4)  
 Missing 23 6      89 17  
BRAF status
 Wild-type 348 (88.1) 78 (72.2) <0.001 N/A N/A   152 27 0.147
 Mutated 47 (11.9) 30 (27.8)   N/A N/A   27 9  
 Missing 24 6      80 15  
  1. Kruskal–Wallis or Mann–Whitney U test applied for continuous variables
  2. MSI microsatellite instability; MSS microsatellite stable