Table 2 Associations of EGFR status with clinicopathological characteristics in three independent CRC patient cohorts
EGFR | Cohort 1 | p value | Cohort 2 | p value | Cohort 3 | p value | |||
|---|---|---|---|---|---|---|---|---|---|
Low | High | Low | High | Low | High | ||||
N (%) | 419 (78.6) | 114 (21.4) | Â | 202 (78.0) | 57 (21.1) | Â | 259 (83.5) | 51 (16.5) | Â |
Age | |||||||||
 Mean, median | 70.6, 71.4 | 69.9, 71.3 | 0.439 | 72.6, 73.5 | 70.7, 73.1 | 0.401 | 71.1, 73.0 | 71.5, 74.0 | 0.977 |
 Range | 51.3–85.6 | 49.8–83.5 |  | 37.6–92.1 | 37.8–93.3 |  | 36.0–94.0 | 50.0–87.0 |  |
Sex | |||||||||
 Female | 219 (52.3) | 62 (54.4) | 0.688 | 98 (48.5) | 34 (59.6) | 0.138 | 129 (49.8) | 29 (56.9) | 0.358 |
 Male | 200 (47.7) | 52 (45.6) |  | 104 (51.5) | 23 (40.4) |  | 130 (50.2) | 22 (43.1) |  |
Location | |||||||||
 Colon | 258 (61.9) | 76 (66.7) | 0.348 | 161 (79.7) | 48 (85.7) | 0.311 | 177 (68.3) | 30 (58.8) | 0.188 |
 Rectum | 159 (38.1) | 38 (33.3) |  | 41 (20.3) | 8 (14.3) |  | 82 (31.7) | 21 (41.2) |  |
 Missing | 2 |  |  |  |  |  |  |  |  |
T-stage | |||||||||
 T1 | 43 (10.9) | 1 (0.9) | <0.001 | 14 (7.1) | 4 (7.1) | 0.432 | 11 (4.2) | 0 (0.0) | 0.002 |
 T2 | 55 (13.9) | 7 (6.2) |  | 53 (26.8) | 11 (19.6) |  | 38 (14.7) | 1 (2.0) |  |
 T3 | 249 (62.9) | 75 (67.0) |  | 107 (54.0) | 33 (58.9) |  | 169 (65.3) | 37 (72.5) |  |
 T4 | 49 (12.4) | 29 (25.9) |  | 24 (14.3) | 8 (14.3) |  | 41 (15.8) | 13 (25.5) |  |
 Missing | 23 | 2 |  | 4 | 1 |  |  |  |  |
N-stage | |||||||||
 N0 | 232 (61.7) | 48 (43.2) | 0.002 | 129 (64.8) | 33 (61.1) | 0.331 | 164 (63.39 | 18 (35.3) | <0.001 |
 N1 | 87 (23.1) | 34 (30.6) |  | 50 (25.1) | 12 (22.2) |  | 53 (20.5) | 9 (17.6) |  |
 N2 | 57 (15.2) | 29 (26.1) |  | 20 (10.1) | 9 (16.7) |  | 42 (16.2) | 24 (47.1) |  |
 Missing | 43 | 3 |  | 3 | 3 |  |  |  |  |
M-stage | |||||||||
 M0 | 349 (84.5) | 82 (72.6) | 0.003 | 180 (89.6) | 40 (72.7) | 0.002 | 232 (89.6) | 39 (76.5) | 0.010 |
 M1 | 64 (15.5) | 31 (27.4) |  | 21 (10.4) | 15 (27.3) |  | 27 (10.4) | 12 (23.5) |  |
 Missing | 6 | 1 |  | 1 | 2 |  |  |  |  |
Diff. grade | |||||||||
 High | 28 (6.8) | 4 (3.6) | <0.001 | 16 (7.9) | 5 (8.8) | 0.402 | 8 (3.1) | 1 (2.0) | 0.006 |
 Intermediate | 310 (75.4) | 62 (55.4) |  | 138 (68.3) | 34 (59.6) |  | 202 (78.0) | 31 (60.8) |  |
 Low | 73 (17.8) | 46 (41.1) |  | 48 (23.8) | 18 (31.6) |  | 49 (18.9) | 19 (37.3) |  |
 Missing | 8 | 2 |  |  |  |  |  |  |  |
Vasc. invasion | |||||||||
 No | 125 (53.2) | 27 (34.2) | 0.003 | 108 (54.8) | 24 (44.4) | 0.177 | 233 (90.0) | 38 (74.5) | 0.002 |
 Yes | 110 (46.8) | 52 (65.8) |  | 89 (45.2) | 30 (55.6) |  | 26 (10.0) | 13 (25.5) |  |
 Missing | 184 | 35 |  | 5 | 3 |  |  |  |  |
MSI status | |||||||||
 MSS | 333 (85.4) | 85 (81.0) | 0.266 | N/A | N/A |  | 214 (82.9) | 47 (92.2) | 0.098 |
 MSI | 57 (14.6) | 20 (19.0) |  | N/A | N/A |  | 44 (17.1) | 4 (7.8) |  |
 Missing | 29 | 9 |  |  |  |  | 1 |  |  |
KRAS status | |||||||||
 Wild-type | 253 (63.9) | 66 (61.1) | 0.596 | N/A | N/A |  | 108 (63.5) | 24 (70.6) | 0.433 |
 Mutated | 119 (36.1) | 42 (38.9) |  | N/A | N/A |  | 62 (36.5) | 10 (29.4) |  |
 Missing | 23 | 6 |  |  |  |  | 89 | 17 |  |
BRAF status | |||||||||
 Wild-type | 348 (88.1) | 78 (72.2) | <0.001 | N/A | N/A |  | 152 | 27 | 0.147 |
 Mutated | 47 (11.9) | 30 (27.8) |  | N/A | N/A |  | 27 | 9 |  |
 Missing | 24 | 6 |  |  |  |  | 80 | 15 |  |